Christos Kourek1, Stavros Dimopoulos1,2, Manal Alshamari1, Virginia Zouganeli3, Katherina Psarra4, Georgios Mitsiou1, Argyrios Ntalianis5, Theodoros Pittaras6, Serafim Nanas1, Eleftherios Karatzanos1. 1. Clinical Ergospirometry, Exercise & Rehabilitation Laboratory, "Evaggelismos" General Hospital, School of Medicine, National and Kapodistrian University of Athens. 2. Cardiac Surgery Intensive Care Unit, "Onassis" Cardiac Surgery Center. 3. 2nd Department of Internal Medicine-Propaedeutic and Diabetes Center, University General Hospital "Attikon", Medical School, National and Kapodistrian University of Athens. 4. Immunology and Histocompatibility Department, "Evaggelismos" General Hospital. 5. Heart Failure Unit, Department of Clinical Therapeutics, "Alexandra" Hospital, National and Kapodistrian University of Athens. 6. Hematology Laboratory-Blood Bank, "Aretaieion" Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Abstract
Purpose: The purpose of this study was to investigate the effect of a cardiac rehabilitation program on the acute response on endothelial progenitor cells and circulating endothelial cells after maximal exercise in patients with chronic heart failure of different severity. Methods: Forty-four chronic heart failure patients were enrolled in a 36-session cardiac rehabilitation program. All patients underwent an initial maximal cardiopulmonary exercise test before and a final maximal cardiopulmonary exercise test after the cardiac rehabilitation program. The patients were divided in two groups of severity according to the median value of peak VO2. Blood was collected at 4 time points; 2 time points at rest, and 2 time points after each cardiopulmonary exercise test. Five endothelial cellular populations were quantified by flow cytometry. Results: Although there was a higher increase in the mobilization of subgroups of endothelial progenitor cells and circulating endothelial cells after the final cardiopulmonary exercise test compared to the initial test within each severity group (p < 0.05), no significant differences between severity groups were observed (p > 0.05). Conclusions: A 36-session cardiac rehabilitation program had similar beneficial effects on the acute response of endothelial progenitor cells and circulating endothelial cells after maximal exercise in patients with chronic heart failure of different severity.
Purpose: The purpose of this study was to investigate the effect of a cardiac rehabilitation program on the acute response on endothelial progenitor cells and circulating endothelial cells after maximal exercise in patients with chronic heart failure of different severity. Methods: Forty-four chronic heart failure patients were enrolled in a 36-session cardiac rehabilitation program. All patients underwent an initial maximal cardiopulmonary exercise test before and a final maximal cardiopulmonary exercise test after the cardiac rehabilitation program. The patients were divided in two groups of severity according to the median value of peak VO2. Blood was collected at 4 time points; 2 time points at rest, and 2 time points after each cardiopulmonary exercise test. Five endothelial cellular populations were quantified by flow cytometry. Results: Although there was a higher increase in the mobilization of subgroups of endothelial progenitor cells and circulating endothelial cells after the final cardiopulmonary exercise test compared to the initial test within each severity group (p < 0.05), no significant differences between severity groups were observed (p > 0.05). Conclusions: A 36-session cardiac rehabilitation program had similar beneficial effects on the acute response of endothelial progenitor cells and circulating endothelial cells after maximal exercise in patients with chronic heart failure of different severity.
Authors: D Morrone; F Felice; C Scatena; A De Martino; M L E Picoi; N Mancini; S Blasi; M Menicagli; R Di Stefano; U Bortolotti; A G Naccarato; A Balbarini Journal: Int J Cardiol Date: 2017-09-14 Impact factor: 4.164
Authors: Kim H Chan; Philippa J L Simpson; Andy S Yong; Louise L Dunn; Chirapan Chawantanpipat; Chijen Hsu; Young Yu; Anthony C Keech; David S Celermajer; Martin K C Ng Journal: PLoS One Date: 2014-04-15 Impact factor: 3.240