Literature DB >> 35867226

Assessment of Tumor Heterogeneity in High-Grade Serous Ovarian Cancer: Mass Cytometry to Understand the Complex Tumor Biology.

Luca Pasquini1, Roberta Riccioni2, Eleonora Petrucci3.   

Abstract

Ovarian cancer (OC) is the most deadly gynecological malignancy worldwide. OC patients undergo debulking surgery followed by platinum/taxane-based chemotherapy; however, despite recent development of new therapeutic approaches based on combination of chemotherapy and innovative targeted-therapies, most of them relapse due to chemoresistance. Many studies have been carried out to decipher the high heterogeneity of ovarian cancer cells that drives tumor treatment failure. Here, we describe our experience in the characterization of ovarian cancer cell subsets through a high-resolution technology in multiparametric analysis, such as mass cytometry (MC).
© 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  CyTOF; Drug resistance; Ovarian cancer; Phenotype; Single-cell mass cytometry; Tumor biomarkers

Mesh：

Substances：

Year:  2022        PMID： 35867226     DOI： 10.1007/978-1-0716-2513-2_9

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  7 in total

Review 1.  Epidemiology of epithelial ovarian cancer.

Authors:  Penelope M Webb; Susan J Jordan
Journal:  Best Pract Res Clin Obstet Gynaecol       Date:  2016-10-03       Impact factor: 5.237

2.  The Cancer Genome Atlas Pan-Cancer analysis project.

Authors:  John N Weinstein; Eric A Collisson; Gordon B Mills; Kenna R Mills Shaw; Brad A Ozenberger; Kyle Ellrott; Ilya Shmulevich; Chris Sander; Joshua M Stuart
Journal:  Nat Genet       Date:  2013-10       Impact factor: 38.330

3.  Mass cytometry: technique for real time single cell multitarget immunoassay based on inductively coupled plasma time-of-flight mass spectrometry.

Authors:  Dmitry R Bandura; Vladimir I Baranov; Olga I Ornatsky; Alexei Antonov; Robert Kinach; Xudong Lou; Serguei Pavlov; Sergey Vorobiev; John E Dick; Scott D Tanner
Journal:  Anal Chem       Date:  2009-08-15       Impact factor: 6.986

Review 4.  The hallmarks of ovarian cancer stem cells and niches: Exploring their harmonious interplay in therapy resistance.

Authors:  Takeshi Motohara; Go J Yoshida; Hidetaka Katabuchi
Journal:  Semin Cancer Biol       Date:  2021-04-01       Impact factor: 15.707

5.  A CD45-based barcoding approach to multiplex mass-cytometry (CyTOF).

Authors:  Liyun Lai; Raymond Ong; Juntao Li; Salvatore Albani
Journal:  Cytometry A       Date:  2015-02-02       Impact factor: 4.355

Review 6.  Key steps and methods in the experimental design and data analysis of highly multi-parametric flow and mass cytometry.

Authors:  Paulina Rybakowska; Marta E Alarcón-Riquelme; Concepción Marañón
Journal:  Comput Struct Biotechnol J       Date:  2020-03-31       Impact factor: 7.271

7.  Commonly Occurring Cell Subsets in High-Grade Serous Ovarian Tumors Identified by Single-Cell Mass Cytometry.

Authors:  Veronica D Gonzalez; Nikolay Samusik; Tiffany J Chen; Erica S Savig; Nima Aghaeepour; David A Quigley; Ying-Wen Huang; Valeria Giangarrà; Alexander D Borowsky; Neil E Hubbard; Shih-Yu Chen; Guojun Han; Alan Ashworth; Thomas J Kipps; Jonathan S Berek; Garry P Nolan; Wendy J Fantl
Journal:  Cell Rep       Date:  2018-02-13       Impact factor: 9.423
  7 in total

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