Literature DB >> 3586574

[Recurrent meningitis in familial deficiency of the 8th component of the complement system].

H Keller, S Löke, G M Hänsch, D Jentschura, H Gerhard, D L Heene.   

Abstract

An 18-year-old man suffered from recurrent bacterial meningitis. Investigation of the complement system revealed deficiency of the 8th complement component (C8) in the patient and his sister. Genetic defects of the terminal complement components C5 to C8 predispose to Neisseria infections, probably due to a lack in bacteriolytic activity. It is to be noted that 1 year ago the patient had been hospitalized for a culture-proved pneumococcal meningitis.

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Year:  1987        PMID： 3586574     DOI： 10.1007/bf01745581

Source DB:  PubMed          Journal:  Klin Wochenschr        ISSN： 0023-2173


  28 in total

1.  Hereditary deficiency of the fifth component of complement in man. I. Clinical, immunochemical, and family studies.

Authors:  S I Rosenfeld; M E Kelly; J P Leddy
Journal:  J Clin Invest       Date:  1976-06       Impact factor: 14.808

2.  Gamma-M deficiency predisposing to meningococcal septicaemia.

Authors:  J R Hobbs; R D Milner; P J Watt
Journal:  Br Med J       Date:  1967-12-09

3.  Chronic meningococcemia. Possible pathogenic role of IgM deficiency.

Authors:  R J Fass; S Saslaw
Journal:  Arch Intern Med       Date:  1972-12

4.  A familial deficiency of the phagocytosis-enhancing activity of serum related to a dysfunction of the fifth component of complement (C5).

Authors:  M E Miller; U R Nilsson
Journal:  N Engl J Med       Date:  1970-02-12       Impact factor: 91.245

5.  Complement deficiency and sporadic meningococcal disease.

Authors: 
Journal:  N Engl J Med       Date:  1983-09-08       Impact factor: 91.245

6.  Recurrent meningococcemia associated with IgG2-subclass deficiency.

Authors:  J L Bass; R Nuss; K A Mehta; P Morganelli; L Bennett
Journal:  N Engl J Med       Date:  1983-08-18       Impact factor: 91.245

7.  The complex of C5b and C6: isolation, characterization, and identification of a modified form of C5b consisting of three polypeptide chains.

Authors:  K I Yamamoto; G Gewurz
Journal:  J Immunol       Date:  1978-06       Impact factor: 5.422

8.  Deficiency of the fifth component of complement in human subjects. Clinical, genetic and immunologic studies in a large kindred.

Authors:  R Snyderman; D T Durack; G A McCarty; F E Ward; L Meadows
Journal:  Am J Med       Date:  1979-10       Impact factor: 4.965

9.  Meningococcal meningitis in familial deficiency of the fifth component of complement.

Authors:  G Peter; M B Weigert; A R Bissel; R Gold; D Kreutzer; R H McLean
Journal:  Pediatrics       Date:  1981-06       Impact factor: 7.124

10.  The eighth component of human complement (C8): isolation, characterization, and hemolytic efficiency.

Authors:  J A Manni; H J Müller-Eberhard
Journal:  J Exp Med       Date:  1969-11-01       Impact factor: 14.307
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  3 in total

1.  Homologous species restriction of the complement-mediated killing of nucleated cells.

Authors:  H Yamamoto; P Blaas; A Nicholson-Weller; G M Hänsch
Journal:  Immunology       Date:  1990-08       Impact factor: 7.397

2.  The C8-binding protein of human erythrocytes: interaction with the components of the complement-attack phase.

Authors:  S Schönermark; S Filsinger; B Berger; G M Hänsch
Journal:  Immunology       Date:  1988-04       Impact factor: 7.397

3.  Interaction of the terminal complement components C5b-9 with synovial fibroblasts: binding to the membrane surface leads to increased levels in collagenase-specific mRNA.

Authors:  B Jahn; J Von Kempis; K L Krämer; S Filsinger; G M Hänsch
Journal:  Immunology       Date:  1993-02       Impact factor: 7.397
  3 in total

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