Literature DB >> 3769133

Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair.

H Kasai, P F Crain, Y Kuchino, S Nishimura, A Ootsuyama, H Tanooka.   

Abstract

8-Hydroxydeoxyguanosine (8-OH-dG) was detected in DNA isolated from HeLa cells after the cells in tissue culture had been irradiated with X-rays and from the liver of mice after the whole animals had been irradiated with gamma-rays. The amounts of 8-OH-dG in DNA after in vivo irradiation were three orders of magnitude lower than those after in vitro irradiation (0.008-0.032 8-OH-dG residue/10(5) dG/krad). The 8-OH-dG produced in liver DNA by irradiation of mice decreased with time, suggesting the presence of a repair enzyme(s) acting on 8-OH-dG in mouse liver. Treatment of Salmonella typhimurium cells with hydrogen peroxide also caused increase in the 8-OH-dG content. These results indicate that 8-OH-dG is formed in vivo in cellular DNA on treatment with various oxygen radical-producing agents and that it is repairable.

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Year:  1986        PMID： 3769133     DOI： 10.1093/carcin/7.11.1849

Source DB:  PubMed          Journal:  Carcinogenesis        ISSN： 0143-3334            Impact factor:   4.944


  167 in total

1.  Inverse radiation dose-rate effects on somatic and germ-line mutations and DNA damage rates.

Authors:  M M Vilenchik; A G Knudson
Journal:  Proc Natl Acad Sci U S A       Date:  2000-05-09       Impact factor: 11.205

2.  Excision of 8-oxoguanine within clustered damage by the yeast OGG1 protein.

Authors:  M H David-Cordonnier; S Boiteux; P O'Neill
Journal:  Nucleic Acids Res       Date:  2001-03-01       Impact factor: 16.971

3.  Protective effects of melatonin against oxidation of guanine bases in DNA and decreased microsomal membrane fluidity in rat liver induced by whole body ionizing radiation.

Authors:  M Karbownik; R J Reiter; W Qi; J J Garcia; D X Tan; L C Manchester
Journal:  Mol Cell Biochem       Date:  2000-08       Impact factor: 3.396

Review 4.  Oxidative damage to RNA in aging and neurodegenerative disorders.

Authors:  Akihiko Nunomura; Paula I Moreira; Rudy J Castellani; Hyoung-Gon Lee; Xiongwei Zhu; Mark A Smith; George Perry
Journal:  Neurotox Res       Date:  2012-06-06       Impact factor: 3.911

5.  Formation of 8-oxo-2'-deoxyguanosine in the DNA of human diploid fibroblasts by treatment with linoleic acid hydroperoxide and ferric ion.

Authors:  T Kaneko; S Tahara
Journal:  Lipids       Date:  2000-09       Impact factor: 1.880

6.  A reliable assessment of 8-oxo-2-deoxyguanosine levels in nuclear and mitochondrial DNA using the sodium iodide method to isolate DNA.

Authors:  M L Hamilton; Z Guo; C D Fuller; H Van Remmen; W F Ward; S N Austad; D A Troyer; I Thompson; A Richardson
Journal:  Nucleic Acids Res       Date:  2001-05-15       Impact factor: 16.971

7.  Singlet oxygen induced mutation spectrum in mammalian cells.

Authors:  R C de Oliveira; D T Ribeiro; R G Nigro; P Di Mascio; C F Menck
Journal:  Nucleic Acids Res       Date:  1992-08-25       Impact factor: 16.971

8.  Hemoglobin and iron handling in brain after subarachnoid hemorrhage and the effect of deferoxamine on early brain injury.

Authors:  Jin-Yul Lee; Richard F Keep; Yangdong He; Oren Sagher; Ya Hua; Guohua Xi
Journal:  J Cereb Blood Flow Metab       Date:  2010-08-25       Impact factor: 6.200

9.  Urinary 8-hydroxy-2'-deoxyguanosine as a biomarker of oxidative DNA damage induced by ambient pollution in the Normative Aging Study.

Authors:  Cizao Ren; Shona Fang; Robert O Wright; Helen Suh; Joel Schwartz
Journal:  Occup Environ Med       Date:  2010-10-27       Impact factor: 4.402

10.  Mechanism of UVA-dependent DNA damage induced by an antitumor drug dacarbazine in relation to its photogenotoxicity.

Authors:  Takuya Iwamoto; Yusuke Hiraku; Masahiro Okuda; Shosuke Kawanishi
Journal:  Pharm Res       Date:  2007-08-21       Impact factor: 4.200
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