| Literature DB >> 3585970 |
A S Al Tuwaijri, A A Mahmoud, I A Al Mofleh, S A Al Khuwaitir.
Abstract
The effect of glucan on Leishmania major infection was studied in BALB/c mice, which are highly susceptible to leishmania infection. Glucan (0.45 mg), or isovolumetric dextrose, was administered intraperitoneally 7, 5, 3 and 1 day before infection with L. major promastigotes. At 3, 5, 6, 8 and 10 weeks after infection, animals were killed; the liver and spleen of each animal were weighed and the parasite burden was calculated. A significant (p less than 0.01) reduction in amastigote proliferation in liver and spleen of animals pretreated with glucan was demonstrated 4, 6 and 8 weeks after infection.Entities:
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Year: 1987 PMID： 3585970 DOI： 10.1099/00222615-23-4-363
Source DB: PubMed Journal: J Med Microbiol ISSN： 0022-2615 Impact factor: 2.472