Literature DB >> 21603320

Glucan-immunostimulant, adjuvant, potential drug.

Vaclav Vetvicka1.   

Abstract

β-glucans belong to a group of biologically active natural compounds called biological response modifiers. These substances represent highly conserved structural components of cell walls in fungi, yeast, grain and seaweed. Despite almost 160 years of intensive research, the exact mechanisms of their action remain unsolved. The significant role of glucans in cancer treatment, infection immunity, stress reduction and restoration of damaged bone marrow has already been established. The present review focuses on the various less known but potentially significant roles glucans might play in medicine. In summary, glucan might represent the most important natural immunomodulator.

Entities:  

Keywords:  Biological Response Modifiers; CR3; Cancer; Glucan; Immunity; Immunomodulators; Resveratrol

Year:  2011        PMID: 21603320      PMCID: PMC3095473          DOI: 10.5306/wjco.v2.i2.115

Source DB:  PubMed          Journal:  World J Clin Oncol        ISSN: 2218-4333


  33 in total

1.  Effect of yeast-derived beta-glucan in conjunction with bevacizumab for the treatment of human lung adenocarcinoma in subcutaneous and orthotopic xenograft models.

Authors:  Wangjian Zhong; Richard Hansen; Bing Li; Yihua Cai; Carolina Salvador; Grace D Moore; Jun Yan
Journal:  J Immunother       Date:  2009-09       Impact factor: 4.456

2.  Inhibition of mouse sarcoma 180 by polysaccharides from Lentinus edodes (Berk.) sing.

Authors:  G Chihara; Y Maeda; J Hamuro; T Sasaki; F Fukuoka
Journal:  Nature       Date:  1969-05-17       Impact factor: 49.962

3.  Clinical evaluation of sizofilan as assistant immunotherapy in treatment of head and neck cancer.

Authors:  Y Kimura; H Tojima; S Fukase; K Takeda
Journal:  Acta Otolaryngol Suppl       Date:  1994

4.  Glucan-induced immunity in mice against Plasmodium berghei.

Authors:  P Kumar; S Ahmad
Journal:  Ann Trop Med Parasitol       Date:  1985-04

Review 5.  Fungal beta-glucans and mammalian immunity.

Authors:  Gordon D Brown; Siamon Gordon
Journal:  Immunity       Date:  2003-09       Impact factor: 31.745

Review 6.  Mushrooms, tumors, and immunity.

Authors:  A T Borchers; J S Stern; R M Hackman; C L Keen; M E Gershwin
Journal:  Proc Soc Exp Biol Med       Date:  1999-09

7.  Physiological effects of different types of beta-glucan.

Authors:  Vaclav Vetvicka; Jana Vetvickova
Journal:  Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub       Date:  2007-12       Impact factor: 1.245

8.  Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation.

Authors:  Myriam Aouadi; Gregory J Tesz; Sarah M Nicoloro; Mengxi Wang; My Chouinard; Ernesto Soto; Gary R Ostroff; Michael P Czech
Journal:  Nature       Date:  2009-04-30       Impact factor: 49.962

9.  The effect of two glucan carboxymethyl derivatives with various substitution degrees on cyclophosphamide immunosuppression in mice.

Authors:  J Wagnerová; A Lísková; J Navarová; A Kristofová; T Trnovec; M Ferencík
Journal:  Immunopharmacol Immunotoxicol       Date:  1993 Mar-Jun       Impact factor: 2.730

10.  Beta-glucan functions as an adjuvant for monoclonal antibody immunotherapy by recruiting tumoricidal granulocytes as killer cells.

Authors:  Feng Hong; Richard D Hansen; Jun Yan; Daniel J Allendorf; Jarek T Baran; Gary R Ostroff; Gordon D Ross
Journal:  Cancer Res       Date:  2003-12-15       Impact factor: 12.701

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  27 in total

1.  Lentinan prolonged survival in patients with gastric cancer receiving S-1-based chemotherapy.

Authors:  Kenji Ina; Ryuichi Furuta; Takae Kataoka; Satoshi Kayukawa; Takashi Yoshida; Takaya Miwa; Yoshitaka Yamamura; Yuuki Takeuchi
Journal:  World J Clin Oncol       Date:  2011-10-10

2.  Sugar-Nanocapsules Imprinted with Microbial Molecular Patterns for mRNA Vaccination.

Authors:  Sejin Son; Jutaek Nam; Ilia Zenkov; Lukasz J Ochyl; Yao Xu; Lindsay Scheetz; Jinjun Shi; Omid C Farokhzad; James J Moon
Journal:  Nano Lett       Date:  2020-02-10       Impact factor: 11.189

3.  Contribution of surface β-glucan polysaccharide to physicochemical and immunomodulatory properties of Propionibacterium freudenreichii.

Authors:  Stéphanie-Marie Deutsch; Sandrine Parayre; Antoine Bouchoux; Fanny Guyomarc'h; Joëlle Dewulf; Marguerite Dols-Lafargue; François Baglinière; Fabien J Cousin; Hélène Falentin; Gwénaël Jan; Benoît Foligné
Journal:  Appl Environ Microbiol       Date:  2012-01-13       Impact factor: 4.792

4.  Purification and partial characterization of a novel β-1,3-endoglucanase from Streptomyces rutgersensis.

Authors:  Artur Javmen; Saulius Grigiskis; Mark Rudenkov; Mykolas Mauricas
Journal:  Protein J       Date:  2013-06       Impact factor: 2.371

Review 5.  Developments in Vaccine Adjuvants.

Authors:  Farrhana Ziana Firdaus; Mariusz Skwarczynski; Istvan Toth
Journal:  Methods Mol Biol       Date:  2022

6.  Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes.

Authors:  Jessica Quintin; Sadia Saeed; Joost H A Martens; Evangelos J Giamarellos-Bourboulis; Daniela C Ifrim; Colin Logie; Liesbeth Jacobs; Trees Jansen; Bart-Jan Kullberg; Cisca Wijmenga; Leo A B Joosten; Ramnik J Xavier; Jos W M van der Meer; Hendrik G Stunnenberg; Mihai G Netea
Journal:  Cell Host Microbe       Date:  2012-08-16       Impact factor: 21.023

7.  Candida albicans primes TLR cytokine responses through a Dectin-1/Raf-1-mediated pathway.

Authors:  Daniela C Ifrim; Leo A B Joosten; Bart-Jan Kullberg; Liesbeth Jacobs; Trees Jansen; David L Williams; Neil A R Gow; Jos W M van der Meer; Mihai G Netea; Jessica Quintin
Journal:  J Immunol       Date:  2013-03-08       Impact factor: 5.422

8.  β-Glucans as Dietary Supplement to Improve Locomotion and Mitochondrial Respiration in a Model of Duchenne Muscular Dystrophy.

Authors:  Letizia Brogi; Maria Marchese; Alessandro Cellerino; Rosario Licitra; Valentina Naef; Serena Mero; Carlo Bibbiani; Baldassare Fronte
Journal:  Nutrients       Date:  2021-05-12       Impact factor: 5.717

Review 9.  The use of lentinan for treating gastric cancer.

Authors:  Kenji Ina; Takae Kataoka; Takafumi Ando
Journal:  Anticancer Agents Med Chem       Date:  2013-06       Impact factor: 2.505

Review 10.  New approaches to the study of sepsis.

Authors:  Peter A Ward
Journal:  EMBO Mol Med       Date:  2012-12       Impact factor: 12.137

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