| Literature DB >> 3585885 |
R I Macleod, R R Welbury, J V Soames.
Abstract
A histological study of 21 teeth from 9 patients who had received cytotoxic chemotherapy for malignant disease showed increased prominence of incremental lines in the dentine. The number and distribution of these lines corresponded to periods of intravenous therapy and vincristine appeared to be the most likely cause. This effect was probably due to temporary disturbance of microtubular function in the odontoblasts resulting in decreased secretion of collagenous dentine matrix. Calcification appeared to be unaffected.Entities:
Mesh：
Year: 1987 PMID： 3585885 PMCID： PMC1290759 DOI： 10.1177/014107688708000405
Source DB: PubMed Journal: J R Soc Med ISSN： 0141-0768 Impact factor: 18.000