Literature DB >> 35848281

Engagement of Foxh1 in chromatin regulation revealed by protein interactome analyses.

Jeff Jiajing Zhou1, Paula Duyen Pham1, Han Han1, Wenqi Wang1, Ken W Y Cho1,2.   

Abstract

Early embryonic cell fates are specified through coordinated integration of transcription factor activities and epigenetic states of the genome. Foxh1 is a key maternal transcription factor controlling the mesendodermal gene regulatory program. Proteomic interactome analyses using FOXH1 as a bait in mouse embryonic stem cells revealed that FOXH1 interacts with PRC2 subunits and HDAC1. Foxh1 physically interacts with Hdac1, and confers transcriptional repression of mesendodermal genes in Xenopus ectoderm. Our findings reveal a central role of Foxh1 in coordinating the chromatin states of the Xenopus embryonic genome.
© 2022 Japanese Society of Developmental Biologists.

Entities:  

Keywords:  HDAC; PRC2; Xenopus; epigenetics; pioneer transcription factors; proteomics

Mesh：

Substances：

Year:  2022        PMID： 35848281      PMCID： PMC9474667          DOI： 10.1111/dgd.12799

Source DB:  PubMed          Journal:  Dev Growth Differ        ISSN： 0012-1592            Impact factor:   3.063


  37 in total

1.  Lsh, a member of the SNF2 family, is required for genome-wide methylation.

Authors:  K Dennis; T Fan; T Geiman; Q Yan; K Muegge
Journal:  Genes Dev       Date:  2001-11-15       Impact factor: 11.361

Review 2.  TGF-beta signalling pathways in early Xenopus development.

Authors:  C S Hill
Journal:  Curr Opin Genet Dev       Date:  2001-10       Impact factor: 5.578

3.  Defining the protein-protein interaction network of the human hippo pathway.

Authors:  Wenqi Wang; Xu Li; Jun Huang; Lin Feng; Keithlee G Dolinta; Junjie Chen
Journal:  Mol Cell Proteomics       Date:  2013-10-14       Impact factor: 5.911

4.  Genome-wide view of TGFβ/Foxh1 regulation of the early mesendoderm program.

Authors:  William T Chiu; Rebekah Charney Le; Ira L Blitz; Margaret B Fish; Yi Li; Jacob Biesinger; Xiaohui Xie; Ken W Y Cho
Journal:  Development       Date:  2014-10-30       Impact factor: 6.868

Review 5.  Erasers of histone acetylation: the histone deacetylase enzymes.

Authors:  Edward Seto; Minoru Yoshida
Journal:  Cold Spring Harb Perspect Biol       Date:  2014-04-01       Impact factor: 10.005

Review 6.  Pioneer Transcription Factors Initiating Gene Network Changes.

Authors:  Kenneth S Zaret
Journal:  Annu Rev Genet       Date:  2020-09-04       Impact factor: 16.830

7.  Foxh1 Occupies cis-Regulatory Modules Prior to Dynamic Transcription Factor Interactions Controlling the Mesendoderm Gene Program.

Authors:  Rebekah M Charney; Elmira Forouzmand; Jin Sun Cho; Jessica Cheung; Kitt D Paraiso; Yuuri Yasuoka; Shuji Takahashi; Masanori Taira; Ira L Blitz; Xiaohui Xie; Ken W Y Cho
Journal:  Dev Cell       Date:  2017-03-17       Impact factor: 12.270

Review 8.  Chromatin modifiers and remodellers: regulators of cellular differentiation.

Authors:  Taiping Chen; Sharon Y R Dent
Journal:  Nat Rev Genet       Date:  2013-12-24       Impact factor: 53.242

Review 9.  Engaging chromatin: PRC2 structure meets function.

Authors:  Paul Chammas; Ivano Mocavini; Luciano Di Croce
Journal:  Br J Cancer       Date:  2019-11-11       Impact factor: 7.640

10.  Expanded encyclopaedias of DNA elements in the human and mouse genomes.

Authors:  Jill E Moore; Michael J Purcaro; Henry E Pratt; Charles B Epstein; Noam Shoresh; Jessika Adrian; Trupti Kawli; Carrie A Davis; Alexander Dobin; Rajinder Kaul; Jessica Halow; Eric L Van Nostrand; Peter Freese; David U Gorkin; Yin Shen; Yupeng He; Mark Mackiewicz; Florencia Pauli-Behn; Brian A Williams; Ali Mortazavi; Cheryl A Keller; Xiao-Ou Zhang; Shaimae I Elhajjajy; Jack Huey; Diane E Dickel; Valentina Snetkova; Xintao Wei; Xiaofeng Wang; Juan Carlos Rivera-Mulia; Joel Rozowsky; Jing Zhang; Surya B Chhetri; Jialing Zhang; Alec Victorsen; Kevin P White; Axel Visel; Gene W Yeo; Christopher B Burge; Eric Lécuyer; David M Gilbert; Job Dekker; John Rinn; Eric M Mendenhall; Joseph R Ecker; Manolis Kellis; Robert J Klein; William S Noble; Anshul Kundaje; Roderic Guigó; Peggy J Farnham; J Michael Cherry; Richard M Myers; Bing Ren; Brenton R Graveley; Mark B Gerstein; Len A Pennacchio; Michael P Snyder; Bradley E Bernstein; Barbara Wold; Ross C Hardison; Thomas R Gingeras; John A Stamatoyannopoulos; Zhiping Weng
Journal:  Nature       Date:  2020-07-29       Impact factor: 69.504
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