Literature DB >> 35841221

Long-term compliance of patients with osteoporosis treatment and its effect to fracture occurrence.

Róbert Čellár1, Erik Dorko2, Kvetoslava Rimárová2, Matúš Bereš1, David Sokol1, Ahmad Gharaibeh1, Martin Folvarský1, István Mitró1, Viliam Knap3.   

Abstract

OBJECTIVES: The objective of this study was to evaluate the effect of long-term treatment of patients with osteoporosis being actively managed by medical staff and following the therapeutic methods and principles of treatment of osteoporosis.
METHODS: The medical records of patients which were examined in an osteological outpatient office first time in the year 2009 were reviewed. The results of densitometry examinations were compared with the results from the year 2019. Patients regularly absolved densitometry, properly and regularly took prescribed medicaments for either anti-osteoporotic treatment or for supplementation of vitamin D and calcium. The cohort consisted of 100 patients. Next, we split the group into 3 categories - less than 65 years of age, 65-75 years of age and lastly over 75 years of age. By default, we assessed and compared the T-scores (deviation from the average value of bone density of 30 years old healthy person) in the area of the proximal femur and in the area of the lumbar spine. The bone mineral density (BMD) values in g/cm2 and their relation to corresponding T-score from set area were also reviewed.
RESULTS: Based on the results of densitometry, osteoporosis was diagnosed in 41 patients, manifest osteoporosis in 14 and osteopenia in 36, nine patients had their bone density value within the normal range. The average T-score values of "total hip" were -1.42, "neck" -2.08, BMD values of "total hip" were 0.802 g/cm2, "L1-L4" -2.05, "L total" -1.45, and BMD of "L total" was 0.886 g/cm2. In the time of the last examination, the T-score (disregarding the type of treatment) raised from the initial value by 40.16% in the area of lumbar spine, by 56.69% in the area of "total hip", and by 40.16% in the area of "neck". While sorting the cohort based on age, we detected a similar effect of active management of treatment in each of the 3 categories.
CONCLUSION: Cooperation of the patients during the treatment of a chronic disease requiring long-term usage of medicaments is often problematic and it is necessary to devote adequate attention to it. The solution to improve the treatment can be active management of the patient by the medical facility or by the medical staff.

Entities:  

Keywords:  compliance; osteoporosis; osteoporosis treatment

Mesh:

Year:  2022        PMID: 35841221     DOI: 10.21101/cejph.a6809

Source DB:  PubMed          Journal:  Cent Eur J Public Health        ISSN: 1210-7778            Impact factor:   1.154


  8 in total

1.  Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025.

Authors:  Russel Burge; Bess Dawson-Hughes; Daniel H Solomon; John B Wong; Alison King; Anna Tosteson
Journal:  J Bone Miner Res       Date:  2007-03       Impact factor: 6.741

Review 2.  Improving drug adherence in osteoporosis: an update on more recent studies.

Authors:  Ayesha Jaleel; Kenneth G Saag; Maria I Danila
Journal:  Ther Adv Musculoskelet Dis       Date:  2018-07-10       Impact factor: 5.346

3.  10 years of denosumab treatment in postmenopausal women with osteoporosis: results from the phase 3 randomised FREEDOM trial and open-label extension.

Authors:  Henry G Bone; Rachel B Wagman; Maria L Brandi; Jacques P Brown; Roland Chapurlat; Steven R Cummings; Edward Czerwiński; Astrid Fahrleitner-Pammer; David L Kendler; Kurt Lippuner; Jean-Yves Reginster; Christian Roux; Jorge Malouf; Michelle N Bradley; Nadia S Daizadeh; Andrea Wang; Paula Dakin; Nicola Pannacciulli; David W Dempster; Socrates Papapoulos
Journal:  Lancet Diabetes Endocrinol       Date:  2017-05-22       Impact factor: 32.069

4.  Compliance with drug therapies for the treatment and prevention of osteoporosis.

Authors:  Jeffrey S McCombs; Patrick Thiebaud; Connie McLaughlin-Miley; Jinhai Shi
Journal:  Maturitas       Date:  2004-07-15       Impact factor: 4.342

5.  Compliance and persistence with oral bisphosphonates for the treatment of osteoporosis in female patients with rheumatoid arthritis.

Authors:  Ji-Heh Park; Eun-Kyoung Park; Dong-Wan Koo; Shinwon Lee; Sun-Hee Lee; Geun-Tae Kim; Seung-Geun Lee
Journal:  BMC Musculoskelet Disord       Date:  2017-04-11       Impact factor: 2.362

6.  Real-world persistence and adherence with oral bisphosphonates for osteoporosis: a systematic review.

Authors:  F Fatoye; P Smith; T Gebrye; G Yeowell
Journal:  BMJ Open       Date:  2019-04-14       Impact factor: 2.692

Review 7.  The Clinical Relevance of Hyperkyphosis: A Narrative Review.

Authors:  M C Koelé; W F Lems; H C Willems
Journal:  Front Endocrinol (Lausanne)       Date:  2020-01-24       Impact factor: 5.555

8.  Persistence at 24 months with denosumab among postmenopausal women with osteoporosis: results of a prospective cohort study.

Authors:  Stuart L Silverman; E Siris; D Belazi; C Recknor; A Papaioannou; J P Brown; D T Gold; E M Lewiecki; G Quinn; A Balasubramanian; S Yue; B Stolshek; D L Kendler
Journal:  Arch Osteoporos       Date:  2018-08-07       Impact factor: 2.617

  8 in total

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