| Literature DB >> 35834026 |
Giandomenico Roviello1, Martina Catalano2, Carlotta Ottanelli2, Roberta Giorgione2, Virginia Rossi3, Elisabetta Gambale3, Chiara Casadei4, Ugo De Giorgi4, Lorenzo Antonuzzo3,5.
Abstract
The treatment landscape for metastatic castration-resistant prostate cancer has evolved extremely in recent years and several drug classes are now available. Nonetheless, the lack of validated predictive biomarkers makes therapeutic choice and the best sequential approach difficult. The location of the metastatic site could be a valid criterion for choosing among the treatment options available. Although bone remains the most frequent metastatic site and a possible target for many drugs, recent data suggest a profound shift in the disease spectrum with visceral metastases increasing incidence. This review describes the presently available and ongoing therapies for patients with CRPC and bone metastases, focusing on the role of bone metastases as a possible driver for selecting therapies in these patients.Entities:
Keywords: 177Lu-PSMA-617; Androgen receptor signaling inhibitors; Bone metastases; Chemotherapy; Metastatic castration-resistant prostate cancer; PARP inhibitors; Sipuleucel-T; radium223
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Year: 2022 PMID: 35834026 DOI: 10.1007/s12032-022-01739-3
Source DB: PubMed Journal: Med Oncol ISSN: 1357-0560 Impact factor: 3.738