Literature DB >> 3581659

Wide spread scars, hypertrophic scars, and keloids.

R Rudolph.   

Abstract

Patients with a wide scar may complain of having a "keloid," yet have a hypertrophic or a wide spread scar. The plastic surgeon should make the appropriate clinical diagnosis, because therapy varies depending on the condition present. A wide spread scar is best treated with excision and closure. A buried dermal flap may help to prevent recurrence, which is nevertheless likely to some degree. A hypertrophic scar can be distinguished from a keloid on clinical grounds. Although both may be red, nodular, and itchy, the keloid overgrows the original wound boundary and is much more likely to recur after surgical excision. Nonsurgical treatment of hypertrophic scars and keloids is similar, using repeated intralesional injections of Kenalog 40 mg per cc and sustained pressure on the lesion when possible. Surgical treatment differs for hypertrophic scars or keloids. Scar excision and closure, and selective Z-plasty, may be used in hypertrophic scars. In keloids, aggressive surgery is usually avoided, unless the lesion has a narrow pedicle. Surgery of keloids should be accompanied by intra- and postoperative Kenalog-40 injections, and on occasion by sustained pressure. Very large keloids may be resistant to medical management, and too aggressive for surgery owing to a high likelihood of recurrence. These difficult lesions serve as the impetus for continued biochemical and tissue culture research, seeking a biochemical means of control keloids.

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Year:  1987        PMID: 3581659

Source DB:  PubMed          Journal:  Clin Plast Surg        ISSN: 0094-1298            Impact factor:   2.017


  12 in total

1.  Liposome associated interferon-alpha-2b functions as an anti-fibrogenic factor in dermal wounds in the guinea pig.

Authors:  A Ghahary; E E Tredget; Q Shen; R T Kilani; P G Scott; M Takeuchi
Journal:  Mol Cell Biochem       Date:  2000-05       Impact factor: 3.396

Review 2.  Skin scarring.

Authors:  A Bayat; D A McGrouther; M W J Ferguson
Journal:  BMJ       Date:  2003-01-11

3.  Mammoplasty in correcting scar-induced breast deformities*.

Authors:  T Abulezz
Journal:  Ann Burns Fire Disasters       Date:  2009-12-31

4.  [Hyperplastic scars and keloids. Part I: basics and prevention].

Authors:  A Baisch; F Riedel
Journal:  HNO       Date:  2006-11       Impact factor: 1.284

5.  A fibroblast cell line cultured from a hypertrophic scar displays selective downregulation of collagen gene expression: barely detectable messenger RNA levels of the pro alpha 1(III) chain of type III collagen.

Authors:  L Q Zhang; M Laato; P Muona; R Penttinen; A Oikarinen; J Peltonen
Journal:  Arch Dermatol Res       Date:  1995       Impact factor: 3.017

6.  Histology of the thick scar on the female, red Duroc pig: final similarities to human hypertrophic scar.

Authors:  Nobuyuki Harunari; Kathy Q Zhu; Rebecca T Armendariz; Heike Deubner; Pornprom Muangman; Gretchen J Carrougher; F Frank Isik; Nicole S Gibran; Loren H Engrav
Journal:  Burns       Date:  2006-08-14       Impact factor: 2.744

Review 7.  The Role of Hypoxia-Inducible Factor in Wound Healing.

Authors:  Wan Xing Hong; Michael S Hu; Mikaela Esquivel; Grace Y Liang; Robert C Rennert; Adrian McArdle; Kevin J Paik; Dominik Duscher; Geoffrey C Gurtner; H Peter Lorenz; Michael T Longaker
Journal:  Adv Wound Care (New Rochelle)       Date:  2014-05-01       Impact factor: 4.730

Review 8.  Review of the female Duroc/Yorkshire pig model of human fibroproliferative scarring.

Authors:  Kathy Q Zhu; Gretchen J Carrougher; Nicole S Gibran; F Frank Isik; Loren H Engrav
Journal:  Wound Repair Regen       Date:  2007 Sep-Oct       Impact factor: 3.617

9.  The role of the TGF-β family in wound healing, burns and scarring: a review.

Authors:  Jack W Penn; Adriaan O Grobbelaar; Kerstin J Rolfe
Journal:  Int J Burns Trauma       Date:  2012-02-05

10.  Treatment of post-burn and post-traumatic atrophic scars with fractional CO2 laser: experience at a tertiary care centre.

Authors:  Abid Keen; Gousia Sheikh; Iffat Hassan; Yasmeen Jabeen; Shagufta Rather; Syed Mubashir; Insha Latif; Sumaya Zeerak; Muzafar Ahmad; Aqib Hassan; Peerzada Ashraf; Faizan Younis; Najamul Saqib
Journal:  Lasers Med Sci       Date:  2018-02-23       Impact factor: 3.161

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