Literature DB >> 35814863

Testability of high-dimensional linear models with nonsparse structures.

Jelena Bradic1, Jianqing Fan2, Yinchu Zhu3.   

Abstract

Understanding statistical inference under possibly non-sparse high-dimensional models has gained much interest recently. For a given component of the regression coefficient, we show that the difficulty of the problem depends on the sparsity of the corresponding row of the precision matrix of the covariates, not the sparsity of the regression coefficients. We develop new concepts of uniform and essentially uniform non-testability that allow the study of limitations of tests across a broad set of alternatives. Uniform non-testability identifies a collection of alternatives such that the power of any test, against any alternative in the group, is asymptotically at most equal to the nominal size. Implications of the new constructions include new minimax testability results that, in sharp contrast to the current results, do not depend on the sparsity of the regression parameters. We identify new tradeoffs between testability and feature correlation. In particular, we show that, in models with weak feature correlations, minimax lower bound can be attained by a test whose power has the n rate, regardless of the size of the model sparsity.

Entities:  

Keywords:  Confidence intervals; Minimax theory; Primary 62C20, 62F03; Secondary 62F30, 62J07; Uniform non-testability; ℓ2-constraint

Year:  2022        PMID: 35814863      PMCID: PMC9266975          DOI: 10.1214/19-aos1932

Source DB:  PubMed          Journal:  Ann Stat        ISSN: 0090-5364            Impact factor:   4.904


  8 in total

Review 1.  Human diseases through the lens of network biology.

Authors:  Laura I Furlong
Journal:  Trends Genet       Date:  2012-12-07       Impact factor: 11.639

Review 2.  Revealing rate-limiting steps in complex disease biology: The crucial importance of studying rare, extreme-phenotype families.

Authors:  Aravinda Chakravarti; Tychele N Turner
Journal:  Bioessays       Date:  2016-04-08       Impact factor: 4.345

Review 3.  An Expanded View of Complex Traits: From Polygenic to Omnigenic.

Authors:  Evan A Boyle; Yang I Li; Jonathan K Pritchard
Journal:  Cell       Date:  2017-06-15       Impact factor: 41.582

4.  Genome-wide prediction and functional characterization of the genetic basis of autism spectrum disorder.

Authors:  Arjun Krishnan; Ran Zhang; Victoria Yao; Chandra L Theesfeld; Aaron K Wong; Alicja Tadych; Natalia Volfovsky; Alan Packer; Alex Lash; Olga G Troyanskaya
Journal:  Nat Neurosci       Date:  2016-08-01       Impact factor: 24.884

5.  EigenPrism: inference for high dimensional signal-to-noise ratios.

Authors:  Lucas Janson; Rina Foygel Barber; Emmanuel Candès
Journal:  J R Stat Soc Series B Stat Methodol       Date:  2016-09-16       Impact factor: 4.488

6.  Structure, function and diversity of the healthy human microbiome.

Authors: 
Journal:  Nature       Date:  2012-06-13       Impact factor: 49.962

Review 7.  False Discovery Rates in PET and CT Studies with Texture Features: A Systematic Review.

Authors:  Anastasia Chalkidou; Michael J O'Doherty; Paul K Marsden
Journal:  PLoS One       Date:  2015-05-04       Impact factor: 3.240

8.  Fast and powerful genome wide association of dense genetic data with high dimensional imaging phenotypes.

Authors:  Habib Ganjgahi; Anderson M Winkler; David C Glahn; John Blangero; Brian Donohue; Peter Kochunov; Thomas E Nichols
Journal:  Nat Commun       Date:  2018-08-14       Impact factor: 14.919

  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.