| Literature DB >> 3580237 |
H M Mathews, I W Carson, P S Collier, J W Dundee, K Fitzpatrick, P J Howard, S M Lyons, I A Orr.
Abstract
Midazolam given as hourly intermittent injections was compared with the same dose given by infusion for postoperative sedation in patients after cardiopulmonary bypass. A stable concentration was rapidly attained with the infusion whereas 6-8 h was required to attain stable plasma (trough) concentrations in the intermittent injection group. Plasma concentrations decreased rapidly to low values within 6 h of discontinuation of therapy. High plasma concentrations and a long (16 h) half-life were noted in one patient who may be a slow metabolizer of the drug.Entities:
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Year: 1987 PMID： 3580237 DOI： 10.1093/bja/59.5.557
Source DB: PubMed Journal: Br J Anaesth ISSN： 0007-0912 Impact factor: 9.166