Literature DB >> 3579604

Relative efficacy of chelating agents as antidotes for acute gallium nitrate intoxication.

J L Domingo, J M Llobet, J Corbella.   

Abstract

Twelve chelating agents were administered to mice by IP injection to compare their relative effectiveness in preventing death after a single IP injection of gallium nitrate. Na2Ca-ethylenediaminetetraacetate (EDTA), Na3Ca-diethylenetriaminepentaacetate (DTPA), dimercaptosuccinic acid (DMSA), 4,5-dihydroxy-1,3-benzene-disulfonic acid (Tiron), sodium diethyldithiocarbamate (DDC), L-cysteine and sodium salicylate were not effective for acute gallium nitrate intoxication. The therapeutic indices of the effective chelators were: 25.4 (deferoxamine mesylate), 35.7 (citric acid), 42.3 (succinic acid), 52.2 (malic acid) and 111.1 (oxalic acid).

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 3579604     DOI： 10.1007/bf00295095

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  16 in total

1.  The tissue distribution of gallium radionuclides.

Authors:  R L Hayes
Journal:  J Nucl Med       Date:  1977-07       Impact factor: 10.057

2.  Comparison of the effectiveness of several chelators after single administration on the toxicity, excretion and distribution of cobalt.

Authors:  J M Llobet; J L Domingo; J Corbella
Journal:  Arch Toxicol       Date:  1986-04       Impact factor: 5.153

3.  Phase I clinical studies with gallium nitrate.

Authors:  A Y Bedikian; M Valdivieso; G P Bodey; M A Burgess; R S Benjamin; S Hall; E J Freireich
Journal:  Cancer Treat Rep       Date:  1978-10

4.  Protection of mice against lethal effects of sodium arsenite--a quantitative comparison of a number of chelating agents.

Authors:  H V Aposhian; C H Tadlock; T E Moon
Journal:  Toxicol Appl Pharmacol       Date:  1981-12       Impact factor: 4.219

5.  Gallium-67 localization in rat and mouse tumors.

Authors:  R L Hayes; B Nelson; D C Swartzendruber; J E Carlton; B L Byrd
Journal:  Science       Date:  1970-01-16       Impact factor: 47.728

6.  Comparison of antidotal efficacy of chelating agents upon acute toxicity of Co(II) in mice.

Authors:  J M Llobet; J L Domingo; J Corbella
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1985-11

7.  Acute aluminium intoxication: a study of the efficacy of several antidotal treatments in mice.

Authors:  J L Domingo; J M Llobet; M Gómez; J Corbella
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1986-07

8.  Kinetics of gallium nitrate, a new anticancer agent.

Authors:  S W Hall; K Yeung; R S Benjamin; D Stewart; M Valdivieso; A Y Bedikian; T L Loo
Journal:  Clin Pharmacol Ther       Date:  1979-01       Impact factor: 6.875

9.  Phase I-II clinical trial of gallium nitrate (NSC-15200).

Authors:  M K Samson; R J Fraile; L H Baker; R O'Bryan
Journal:  Cancer Clin Trials       Date:  1980

10.  Treatment of patients with advanced malignant lymphoma using gallium nitrate administered as a seven-day continuous infusion.

Authors:  R P Warrell; C J Coonley; D J Straus; C W Young
Journal:  Cancer       Date:  1983-06-01       Impact factor: 6.860
View more
  1 in total

Review 1.  Gallium nitrate. A review of its pharmacological properties and therapeutic potential in cancer related hypercalcaemia.

Authors:  P A Todd; A Fitton
Journal:  Drugs       Date:  1991-08       Impact factor: 9.546
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.