Yi-Yan Pei1, Yu Zhang2, Zhe-Ran Liu1, Yan He1, Jia-Yi Yu3, Ren-Jie Zhang4, Jing-Jing Wang1, Xing-Chen Peng5, Fang Fang6. 1. Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, China. 2. Department of Neurosurgery, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China. 3. School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China. 4. Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China. 5. Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, China. pxx2014@163.com. 6. Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China. fangfang01@scu.edu.cn.
Abstract
BACKGROUND: Lactate dehydrogenase (LDH) is a biomarker for cancer. However, the relationship between serum LDH levels and the survival of patients with brain metastasis has been fully revealed. We aimed to evaluate the serum LDH levels and assess its prognostic value in patients with BM. METHODS: The serum LDH levels were collected from 2507 patients with BM. Patients were categorized into four groups according to the quartile of serum LDH levels. The association between serum LDH levels and overall survival (OS) was evaluated using Cox regression models and Kaplan-Meier curves. Three predictive models were used to evaluate patients. RESULTS: The Kaplan-Meier curve for survival by the serum LDH group demonstrates clear separation between four groups (P < 0.001). The participants in the lower group had longer OS than those in the higher group. After adjusting in multivariate Cox regression models remained significant for patients in the Q4 compared with patients in the Q1 (Q4:Q1 OR 1.58, 95% CI 1.38-1.80). Furthermore, the GPA-LDH model generates a pooled area under the curve of 0.630 (95% CI 0.600, 0.660). CONCLUSIONS: Serum LDH levels and OS in patients with brain metastasis is an inverse association. Moreover, Serum LDH levels can improve the prognosis of the GPA model.
BACKGROUND: Lactate dehydrogenase (LDH) is a biomarker for cancer. However, the relationship between serum LDH levels and the survival of patients with brain metastasis has been fully revealed. We aimed to evaluate the serum LDH levels and assess its prognostic value in patients with BM. METHODS: The serum LDH levels were collected from 2507 patients with BM. Patients were categorized into four groups according to the quartile of serum LDH levels. The association between serum LDH levels and overall survival (OS) was evaluated using Cox regression models and Kaplan-Meier curves. Three predictive models were used to evaluate patients. RESULTS: The Kaplan-Meier curve for survival by the serum LDH group demonstrates clear separation between four groups (P < 0.001). The participants in the lower group had longer OS than those in the higher group. After adjusting in multivariate Cox regression models remained significant for patients in the Q4 compared with patients in the Q1 (Q4:Q1 OR 1.58, 95% CI 1.38-1.80). Furthermore, the GPA-LDH model generates a pooled area under the curve of 0.630 (95% CI 0.600, 0.660). CONCLUSIONS: Serum LDH levels and OS in patients with brain metastasis is an inverse association. Moreover, Serum LDH levels can improve the prognosis of the GPA model.
Authors: Y Yu; J A Deck; L A Hunsaker; L M Deck; R E Royer; E Goldberg; D L Vander Jagt Journal: Biochem Pharmacol Date: 2001-07-01 Impact factor: 5.858
Authors: Peter E Fecci; Cosette D Champion; Jacob Hoj; Courtney M McKernan; C Rory Goodwin; John P Kirkpatrick; Carey K Anders; Ann Marie Pendergast; John H Sampson Journal: Clin Cancer Res Date: 2019-06-18 Impact factor: 12.531
Authors: Paul W Sperduto; Shane Mesko; Jing Li; Daniel Cagney; Ayal Aizer; Nancy U Lin; Eric Nesbit; Tim J Kruser; Jason Chan; Steve Braunstein; Jessica Lee; John P Kirkpatrick; Will Breen; Paul D Brown; Diana Shi; Helen A Shih; Hany Soliman; Arjun Sahgal; Ryan Shanley; William A Sperduto; Emil Lou; Ashlyn Everett; Drexell H Boggs; Laura Masucci; David Roberge; Jill Remick; Kristin Plichta; John M Buatti; Supriya Jain; Laurie E Gaspar; Cheng-Chia Wu; Tony J C Wang; John Bryant; Michael Chuong; Yi An; Veronica Chiang; Toshimichi Nakano; Hidefumi Aoyama; Minesh P Mehta Journal: J Clin Oncol Date: 2020-09-15 Impact factor: 44.544
Authors: Han Xie; Jun-Ichi Hanai; Jian-Guo Ren; Lev Kats; Kerri Burgess; Parul Bhargava; Sabina Signoretti; Julia Billiard; Kevin J Duffy; Aaron Grant; Xiaoen Wang; Pawel K Lorkiewicz; Sabrina Schatzman; Michael Bousamra; Andrew N Lane; Richard M Higashi; Teresa W M Fan; Pier Paolo Pandolfi; Vikas P Sukhatme; Pankaj Seth Journal: Cell Metab Date: 2014-04-10 Impact factor: 27.287