Tissue penetration and metabolism of ciprofloxacin.

The tissue penetration of ciprofloxacin was studied by two methods. Penetration into inflammatory fluid following oral administration (500 mg) was 117 percent; following intravenous administration (100 mg), penetration was 121 percent. The penetration of ciprofloxacin into uninflamed peritoneum following intravenous administration (100 mg) was 95 percent.