Literature DB >> 2729952

Enhanced elimination of ciprofloxacin after multiple-dose administration of rifampin to rabbits.

S L Barriere1, G W Kaatz, S M Seo.   

Abstract

The combination of ciprofloxacin and rifampin is potentially useful for the treatment of selected infections. However, rifampin may induce the metabolism of ciprofloxacin. Ciprofloxacin was given in single doses to healthy rabbits before and after six daily doses of intramuscular rifampin. Total clearance of ciprofloxacin increased from 0.96 +/- 0.32 (standard deviation) to 1.57 +/- 0.63 liters/h per kg (P less than 0.05). This change in elimination is potentially significant for the outcome of experimental infections in rabbits.

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Year:  1989        PMID： 2729952      PMCID： PMC172487          DOI： 10.1128/AAC.33.4.589

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

1.  Treatment of methicillin-resistant Staphylococcus aureus experimental osteomyelitis with ciprofloxacin or vancomycin alone or in combination with rifampin.

Authors:  N K Henry; M S Rouse; A L Whitesell; M E McConnell; W R Wilson
Journal:  Am J Med       Date:  1987-04-27       Impact factor: 4.965

2.  Correlation of antimicrobial pharmacokinetic parameters with therapeutic efficacy in an animal model.

Authors:  B Vogelman; S Gudmundsson; J Leggett; J Turnidge; S Ebert; W A Craig
Journal:  J Infect Dis       Date:  1988-10       Impact factor: 5.226

Review 3.  Mycobacterium avium complex infection.

Authors:  L S Young
Journal:  J Infect Dis       Date:  1988-05       Impact factor: 5.226

4.  Activity of ciprofloxacin and other fluorinated quinolones against mycobacteria.

Authors:  L S Young; O G Berlin; C B Inderlied
Journal:  Am J Med       Date:  1987-04-27       Impact factor: 4.965

Review 5.  Rifampin drug interactions.

Authors:  A M Baciewicz; T H Self
Journal:  Arch Intern Med       Date:  1984-08

6.  Chronic staphylococcal osteomyelitis: treatment with regimens containing rifampin.

Authors:  C W Norden; J Fierer; R E Bryant
Journal:  Rev Infect Dis       Date:  1983 Jul-Aug

7.  Altered pharmacokinetic disposition of ciprofloxacin and vancomycin after single and multiple doses in rabbits.

Authors:  S L Barriere; G W Kaatz; D R Schaberg; R Fekety
Journal:  Antimicrob Agents Chemother       Date:  1987-07       Impact factor: 5.191

Review 8.  Pharmacokinetics and metabolism of rifampin in humans.

Authors:  G Acocella
Journal:  Rev Infect Dis       Date:  1983 Jul-Aug

9.  The antimicrobial activity of rifampin: emphasis on the relation to phagocytes.

Authors:  G L Mandell
Journal:  Rev Infect Dis       Date:  1983 Jul-Aug

10.  The antimicrobial activity of ciprofloxacin against Legionella species and the treatment of experimental Legionella pneumonia in guinea pigs.

Authors:  A Saito; H Koga; H Shigeno; K Watanabe; K Mori; S Kohno; Y Shigeno; Y Suzuyama; K Yamaguchi; M Hirota
Journal:  J Antimicrob Chemother       Date:  1986-08       Impact factor: 5.790
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  3 in total

1.  Multiple-dose pharmacokinetics of concurrent oral ciprofloxacin and rifampin therapy in elderly patients.

Authors:  M H Chandler; S M Toler; R P Rapp; R R Muder; J A Korvick
Journal:  Antimicrob Agents Chemother       Date:  1990-03       Impact factor: 5.191

2.  Randomized pharmacokinetic and pharmacodynamic comparison of fluoroquinolones for tuberculous meningitis.

Authors:  Guy E Thwaites; Sujata M Bhavnani; Tran Thi Hong Chau; Jeffrey P Hammel; M Estée Török; Scott A Van Wart; Pham Phuong Mai; Daniel K Reynolds; Maxine Caws; Nguyen Thi Dung; Tran Tinh Hien; Robert Kulawy; Jeremy Farrar; Paul G Ambrose
Journal:  Antimicrob Agents Chemother       Date:  2011-04-18       Impact factor: 5.191

3.  Influence of rifampin on fleroxacin pharmacokinetics.

Authors:  J Schrenzel; P Dayer; T Leemann; E Weidekamm; R Portmann; D P Lew
Journal:  Antimicrob Agents Chemother       Date:  1993-10       Impact factor: 5.191
  3 in total

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