Madeleine Petersson-Sjögren1,2, Jonas Jakobsson3, H Laura Aaltonen4,5, Hanna Nicklasson6,7, Jenny Rissler1,2,8, Gunnar Engström9, Per Wollmer6, Jakob Löndahl1,2. 1. Division of Ergonomics and Aerosol Technology, Department of Design Sciences, Lund University, Lund, Sweden. 2. NanoLund, Lund University, Lund, Sweden. 3. Division of Nuclear Physics, Department of Physics, Lund University, Lund, Sweden. 4. Department of Translational Medicine, Medical Imaging and Physiology, Lund University, Malmö, Sweden. 5. Department of Radiology, University of Washington, Seattle, WA, USA. 6. Department of Translational Medicine, Clinical Physiology and Nuclear Medicine, Skåne University Hospital, Malmö, Sweden. 7. MVIC Medicon Valley Inhalation Consortium AB, Lund, Sweden. 8. Division of Bioeconomy and Health, RISE Research Institutes of Sweden, Borås, Sweden. 9. Department of Clinical Sciences, Lund University, Malmö, Sweden.
Abstract
Background: Airspace Dimensions Assessment with nanoparticles (AiDA) is a new method for non-invasive measurement of pulmonary distal airspaces. The aim of this study was to compare AiDA measurements with other pulmonary function variables to better understand the potential of AiDA in a clinical context. Methods: AiDA measurements and pulmonary function tests were performed in 695 subjects as part of the Swedish CArdioPulmonary bioImage Study. The measurement protocol included spirometry, measurement of diffusing capacity of carbon monoxide, oscillometry and pulmonary computed tomography. AiDA indices were compared to all other pulmonary examination measurements using multivariate statistical analysis. Results: Our results show that AiDA measurements were significantly correlated with other pulmonary function examination indices, although covariance was low. We found that AiDA variables explained variance in the data that other lung function variables only influenced to a minor extent. Conclusion: We conclude that the AiDA method provides information about the lung that is inaccessible with more conventional lung function techniques.
Background: Airspace Dimensions Assessment with nanoparticles (AiDA) is a new method for non-invasive measurement of pulmonary distal airspaces. The aim of this study was to compare AiDA measurements with other pulmonary function variables to better understand the potential of AiDA in a clinical context. Methods: AiDA measurements and pulmonary function tests were performed in 695 subjects as part of the Swedish CArdioPulmonary bioImage Study. The measurement protocol included spirometry, measurement of diffusing capacity of carbon monoxide, oscillometry and pulmonary computed tomography. AiDA indices were compared to all other pulmonary examination measurements using multivariate statistical analysis. Results: Our results show that AiDA measurements were significantly correlated with other pulmonary function examination indices, although covariance was low. We found that AiDA variables explained variance in the data that other lung function variables only influenced to a minor extent. Conclusion: We conclude that the AiDA method provides information about the lung that is inaccessible with more conventional lung function techniques.
Authors: K de Bruijne; S Ebersviller; K G Sexton; S Lake; D Leith; R Goodman; J Jetters; G W Walters; M Doyle-Eisele; R Woodside; H E Jeffries; I Jaspers Journal: Inhal Toxicol Date: 2009-02 Impact factor: 2.724
Authors: Gregory G King; Jason Bates; Kenneth I Berger; Peter Calverley; Pedro L de Melo; Raffaele L Dellacà; Ramon Farré; Graham L Hall; Iulia Ioan; Charles G Irvin; David W Kaczka; David A Kaminsky; Hajime Kurosawa; Enrico Lombardi; Geoffrey N Maksym; François Marchal; Beno W Oppenheimer; Shannon J Simpson; Cindy Thamrin; Maarten van den Berge; Ellie Oostveen Journal: Eur Respir J Date: 2020-02-27 Impact factor: 16.671
Authors: B T Saam; D A Yablonskiy; V D Kodibagkar; J C Leawoods; D S Gierada; J D Cooper; S S Lefrak; M S Conradi Journal: Magn Reson Med Date: 2000-08 Impact factor: 4.668
Authors: H L Aaltonen; J K Jakobsson; S Diaz; S Zackrisson; E Piitulainen; J Löndahl; P Wollmer Journal: Clin Physiol Funct Imaging Date: 2018-04-10 Impact factor: 2.273
Authors: Madeleine Petersson-Sjögren; Ho-Fung Chan; Guilhem J Collier; Graham Norquay; Lars E Olsson; Per Wollmer; Jakob Löndahl; Jim M Wild Journal: Sci Rep Date: 2021-02-25 Impact factor: 4.379
Authors: H Laura Aaltonen; Madeleine Petersson Sjögren; Jonas K F Jakobsson; Hanna Nicklasson; Sandra Diaz; Francisco Sánchez Montiel; Sophia Zackrisson; Veronica Ideböhn; Gunnar Engström; Jakob Löndahl; Per Wollmer Journal: Thorax Date: 2021-04-15 Impact factor: 9.139