H L Aaltonen1,2, J K Jakobsson3, S Diaz1,2, S Zackrisson1,2, E Piitulainen4, J Löndahl3, P Wollmer1,2. 1. Department of Medical Imaging and Physiology, Skåne University Hospital, Malmö, Sweden. 2. Department of Translational Medicine, Lund University, Malmö, Sweden. 3. Division of Ergonomics and Aerosol Technology, Department of Design Sciences, Faculty of Engineering LTH, Lund University, Lund, Sweden. 4. Department of Respiratory Medicine and Allergology, Lund University, Lund, Sweden.
Abstract
BACKGROUND: The diagnosis of chronic obstructive pulmonary disease (COPD) is often based on spirometry, which is not sensitive to early emphysema. We have recently described a method for assessing distal airspace dimensions by measuring recovery of nanoparticles in exhaled air after a single-breath inhalation followed by breath-hold. Recovery refers to the non-deposited particle fraction. The aim of this study was to explore differences in the recovery of exhaled nanoparticles in subjects with COPD and never-smoking controls. A secondary aim was to determine whether recovery correlates with the extent of emphysema. METHOD: A total of 19 patients with COPD and 19 controls underwent three repeats of single-breath nanoparticle inhalation followed by breath-hold. Particle concentrations in the inhaled aerosol, and in an alveolar sample exhaled after breath-hold, were measured to obtain recovery. FINDINGS: The patients with COPD had a significantly higher mean recovery than controls, 0·128 ± 0·063 versus 0·074 ± 0·058; P = 0·010. Also, recovery correlated significantly with computed tomography (CT) densitometry variables (P<0·01) and diffusing capacity for carbon monoxide (DL,CO ; P = 0·002). INTERPRETATION: Higher recovery for emphysema patients, relative to controls, is explained by larger diffusion distances in enlarged distal airspaces. The nanoparticle inhalation method shows potential to be developed towards a tool to diagnose emphysema.
BACKGROUND: The diagnosis of chronic obstructive pulmonary disease (COPD) is often based on spirometry, which is not sensitive to early emphysema. We have recently described a method for assessing distal airspace dimensions by measuring recovery of nanoparticles in exhaled air after a single-breath inhalation followed by breath-hold. Recovery refers to the non-deposited particle fraction. The aim of this study was to explore differences in the recovery of exhaled nanoparticles in subjects with COPD and never-smoking controls. A secondary aim was to determine whether recovery correlates with the extent of emphysema. METHOD: A total of 19 patients with COPD and 19 controls underwent three repeats of single-breath nanoparticle inhalation followed by breath-hold. Particle concentrations in the inhaled aerosol, and in an alveolar sample exhaled after breath-hold, were measured to obtain recovery. FINDINGS: The patients with COPD had a significantly higher mean recovery than controls, 0·128 ± 0·063 versus 0·074 ± 0·058; P = 0·010. Also, recovery correlated significantly with computed tomography (CT) densitometry variables (P<0·01) and diffusing capacity for carbon monoxide (DL,CO ; P = 0·002). INTERPRETATION: Higher recovery for emphysemapatients, relative to controls, is explained by larger diffusion distances in enlarged distal airspaces. The nanoparticle inhalation method shows potential to be developed towards a tool to diagnose emphysema.
Authors: Madeleine Petersson-Sjögren; Jonas Jakobsson; H Laura Aaltonen; Hanna Nicklasson; Jenny Rissler; Gunnar Engström; Per Wollmer; Jakob Löndahl Journal: Int J Nanomedicine Date: 2022-06-25
Authors: Madeleine Petersson-Sjögren; Ho-Fung Chan; Guilhem J Collier; Graham Norquay; Lars E Olsson; Per Wollmer; Jakob Löndahl; Jim M Wild Journal: Sci Rep Date: 2021-02-25 Impact factor: 4.379
Authors: H Laura Aaltonen; Simon S Kindvall; Jonas K Jakobsson; Jakob Löndahl; Lars E Olsson; Sandra Diaz; Sophia Zackrisson; Per Wollmer Journal: Int J Nanomedicine Date: 2018-05-21
Authors: Jonas K F Jakobsson; H Laura Aaltonen; Hanna Nicklasson; Anders Gudmundsson; Jenny Rissler; Per Wollmer; Jakob Löndahl Journal: BMC Pulm Med Date: 2018-08-06 Impact factor: 3.317
Authors: H Laura Aaltonen; Madeleine Petersson Sjögren; Jonas K F Jakobsson; Hanna Nicklasson; Sandra Diaz; Francisco Sánchez Montiel; Sophia Zackrisson; Veronica Ideböhn; Gunnar Engström; Jakob Löndahl; Per Wollmer Journal: Thorax Date: 2021-04-15 Impact factor: 9.139