| Literature DB >> 35781943 |
Simon Skyrman1,2, Gustav Burström1,2, Oskar Aspegren3,4, Drazenko Babic5, Gerald Lucassen5, Erik Edström1,2, Fabian Arnberg1,2, Marcus Ohlsson1,2, Manfred Mueller5, Adrian Elmi-Terander1,2, Tommy Andersson1,2,1,6.
Abstract
Acute ischemic stroke caused by large vessel occlusion is treated with endovascular thrombectomy, but treatment failure may occur when clot composition and thrombectomy technique mismatch. In this proof-of-concept study, diffuse reflectance spectroscopy (DRS) is evaluated for identification of clot composition ex vivo. DRS spectra and histology were acquired from 45 clot units retrieved from 29 stroke patients. DRS spectra correlated to clot RBC content, R= 81, p < .001, and could discriminate between RBC-rich and fibrin-rich clots, p < 0.001. Sensitivity and specificity for detection of RBC-rich clots were 0.722 and 0.846 respectively. Applied in an intravascular device, DRS could potentially provide intraprocedural information on clot composition that could increase endovascular thrombectomy efficiency.Entities:
Year: 2022 PMID： 35781943 PMCID： PMC9208598 DOI： 10.1364/BOE.458445
Source DB: PubMed Journal: Biomed Opt Express ISSN： 2156-7085 Impact factor: 3.562