Ljubica Djukanović1,2, Višnja Ležaić3,4, Nada Dimković3,4, Jelena Marinković4, Biserka Aksić Milićević5, Svetlana Arsenijević6, Aleksandra Arsenović7, Biljana Ceković6, Dejan Ćelić8,9, Verica Djordjević10, Miloš Djurin11, Nenad Filipović12, Selena Gajić13, Branimir Haviža-Lilić14, Miloš Jandrić15, Nasta Jovanović16, Violeta Knežević8,9, Svetlana Krsmanović17, Dragana Marković18, Djoko Maksić19, Jelena Maslovarić20, Snežana Milanović21, Branka Mitić22, Ana Ostojić23, Dobrila Petković24, Dragana Pilipović25, Miodrag Sokolović26, Dragana Stanković27, Marina Stojanović28, Tatjana Stojšić Vuksanović29, Biserka Tirmenštajn30, Jadranka Uzelac25, Nataša Vesić31, Goran Vojinović32, Vanja Vukša33. 1. Academy of Medical Sciences of Serbian Medical Society, Belgrade, Serbia. ljubicadjukanovic@yahoo.com. 2. School of Medicine, University of Belgrade, Dr Subotica 8, 11 000, Belgrade, Serbia. ljubicadjukanovic@yahoo.com. 3. Academy of Medical Sciences of Serbian Medical Society, Belgrade, Serbia. 4. School of Medicine, University of Belgrade, Dr Subotica 8, 11 000, Belgrade, Serbia. 5. Nephrology Ward, General Hospital, Kraljevo, Serbia. 6. Nephrology Ward, General Hospital, Čačak, Serbia. 7. Special Hospital of Internal Medicine, Lazarevac, Serbia. 8. Clinic of Nephrology and Clinical Immunology, Univeristy Clinical Center of Vojvodina, Novi Sad, Serbia. 9. Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia. 10. Nephrology Ward, General Hospital, Smederevska Palanka, Serbia. 11. Nephrology Ward, General Hospital, Kikinda, Serbia. 12. Nephrology Ward, General Hospital, Loznica, Serbia. 13. Department of Nephrology, University Clinical Center of Serbia, Belgrade, Serbia. 14. Nephrology Ward, General Hospital, Pirot, Serbia. 15. Nephrology Ward, General Hospital, Sombor, Serbia. 16. Nephrology Ward, Health Center, Žagubica, Serbia. 17. Nephrology Ward, Health Center, Priboj, Serbia. 18. Department of Nephrology, Zvezdara Clinical Hospital Center, Belgrade, Serbia. 19. Department of Nephrology, Military Medical Academy, Belgrade, Serbia. 20. FMC Special Hemodialysis Hospital, Belgrade, Serbia. 21. Nephrology Ward, General Hospital, Užice, Serbia. 22. Department of Nephrology, University Clinical Center, Niš, Serbia. 23. Nephrology Department, Zemun Clinical Hospital Center, Zemun-Belgrade, Serbia. 24. FMC Special Hemodialysis Hospital, Novi Sad, Serbia. 25. Nephrology Ward, Health Center, Bačka Palanka, Serbia. 26. Nephrology Ward, General Hospital, Leskovac, Serbia. 27. Nephrology Ward, General Hospital, Šabac, Serbia. 28. Nephrology Ward, General Hospital, Mladenovac, Serbia. 29. Nephrology Ward, General Hospital, Subotica, Serbia. 30. Nephrology Ward, General Hospital, Zaječar, Serbia. 31. Nephrology Ward, General Hospital, Valjevo, Serbia. 32. Nephrology Ward, General Hospital, Pančevo, Serbia. 33. Medicon Special Hemodialysis Hospital, Belgrade, Serbia.
Abstract
PURPOSE: The study was undertaken with the aim to determine gender-specific differences in incident hemodialysis (HD) patient and their changes over time. METHODS: The retrospective longitudinal closed cohort study involved 441 incident patients starting HD in 2014 and followed for 1-59 (median 43, IQR 40) months. Demographic, clinical data, treatment characteristics, laboratory findings and outcome were abstracted from the patients' medical records. RESULTS: The relative number of males on HD was about twice that of females throughout the five years investigated. At the beginning of the study, no significant differences were found in the main demographic and clinical characteristics except that diabetes was more often the underlying disease in men than in women. Systolic blood pressure decreased over time significantly more in females than in males. Throughout the study spKt/V was significantly higher in females than in males, but it increased in patients of both genders. There were no gender differences for comorbidities, vascular access and the majority of laboratory findings except for higher serum levels of creatinine and CRP in men than in women. Relatively more females were treated with erythropoiesis stimulating agents and phosphate binders than males. Age and malignancy were selected as significant predictors of mortality for both genders, and, in addition, polycystic kidney disease, serum level of albumin and CRP for men, but spKt/V for women. CONCLUSION: Some significant gender differences were observed throughout, while others appeared during the study but none of them were due to gender inequalities in the applied treatment.
PURPOSE: The study was undertaken with the aim to determine gender-specific differences in incident hemodialysis (HD) patient and their changes over time. METHODS: The retrospective longitudinal closed cohort study involved 441 incident patients starting HD in 2014 and followed for 1-59 (median 43, IQR 40) months. Demographic, clinical data, treatment characteristics, laboratory findings and outcome were abstracted from the patients' medical records. RESULTS: The relative number of males on HD was about twice that of females throughout the five years investigated. At the beginning of the study, no significant differences were found in the main demographic and clinical characteristics except that diabetes was more often the underlying disease in men than in women. Systolic blood pressure decreased over time significantly more in females than in males. Throughout the study spKt/V was significantly higher in females than in males, but it increased in patients of both genders. There were no gender differences for comorbidities, vascular access and the majority of laboratory findings except for higher serum levels of creatinine and CRP in men than in women. Relatively more females were treated with erythropoiesis stimulating agents and phosphate binders than males. Age and malignancy were selected as significant predictors of mortality for both genders, and, in addition, polycystic kidney disease, serum level of albumin and CRP for men, but spKt/V for women. CONCLUSION: Some significant gender differences were observed throughout, while others appeared during the study but none of them were due to gender inequalities in the applied treatment.
Authors: Ana C Ricardo; Wei Yang; Daohang Sha; Lawrence J Appel; Jing Chen; Marie Krousel-Wood; Anjella Manoharan; Susan Steigerwalt; Jackson Wright; Mahboob Rahman; Sylvia E Rosas; Milda Saunders; Kumar Sharma; Martha L Daviglus; James P Lash Journal: J Am Soc Nephrol Date: 2018-12-03 Impact factor: 10.121
Authors: Daniel Murphy; Charles E McCulloch; Feng Lin; Tanushree Banerjee; Jennifer L Bragg-Gresham; Mark S Eberhardt; Hal Morgenstern; Meda E Pavkov; Rajiv Saran; Neil R Powe; Chi-Yuan Hsu Journal: Ann Intern Med Date: 2016-08-02 Impact factor: 25.391
Authors: Manfred Hecking; Brian A Bieber; Jean Ethier; Alexandra Kautzky-Willer; Gere Sunder-Plassmann; Marcus D Säemann; Sylvia P B Ramirez; Brenda W Gillespie; Ronald L Pisoni; Bruce M Robinson; Friedrich K Port Journal: PLoS Med Date: 2014-10-28 Impact factor: 11.069