Nguyen Thanh Tung1,2, Shang-Yang Lin3, Hoang Ba Dung2, Tran Phan Chung Thuy4, Yi-Chun Kuan5, Cheng-Yu Tsai6, Chen-Chen Lo3,7, Kang Lo3,7, Wen-Te Liu8,9,10, Hsiao-Chi Chuang11,12,13. 1. International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. 2. Otorhinolaryngology Department, Cho Ray Hospital, Ho Chi Minh City, Vietnam. 3. Sleep Center, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan. 4. Otorhinolaryngology Department, Faculty of Medicine, Vietnam National University Ho Chi Minh City, Ho Chi Minh City, Vietnam. 5. Department of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan. 6. Department of Civil and Environmental Engineering, Imperial College London, London, UK. 7. School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan. 8. Sleep Center, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan. lion5835@gmail.com. 9. School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan. lion5835@gmail.com. 10. Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan. lion5835@gmail.com. 11. School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan. chuanghc@tmu.edu.tw. 12. Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan. chuanghc@tmu.edu.tw. 13. Cell Physiology and Molecular Image Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. chuanghc@tmu.edu.tw.
Abstract
PURPOSE: Body composition is considered to be associated with obstructive sleep apnea (OSA) severity. This cross-sectional study aimed to examine associations of overnight body composition changes with positional OSA. METHODS: The body composition of patients diagnosed with non-positional and positional OSA was measured before and after overnight polysomnography. Odds ratios (ORs) of outcome variables between the case (positional OSA) and reference (non-positional OSA) groups were examined for associations with sleep-related parameters and with changes in body composition by a logistic regression analysis. RESULTS: Among 1584 patients with OSA, we used 1056 patients with non-positional OSA as the reference group. We found that a 1-unit increase in overnight changes of total fat percentage and total fat mass were associated with 1.076-fold increased OR (95% confidence interval (CI): 1.014, 1.142) and 1.096-fold increased OR (95% CI: 1.010, 1.189) of positional OSA, respectively (all p < 0.05). Additionally, a 1-unit increase in overnight changes of lower limb fat percentage and upper limb fat mass were associated with 1.043-fold increased OR (95% CI: 1.004, 1.084) and 2.638-fold increased OR (95% CI: 1.313, 5.302) of positional OSA, respectively (all p < 0.05). We observed that a 1-unit increase in overnight changes of trunk fat percentage and trunk fat mass were associated with 1.056-fold increased OR (95% CI: 1.008, 1.106) and 1.150-fold increased OR (95% CI: 1.016, 1.301) of positional OSA, respectively (all p < 0.05). CONCLUSION: Our findings indicated that nocturnal changes in the body's composition, especially total fat mass, total fat percentage, lower limb fat percentage, upper limb fat mass, trunk fat percentage, and trunk fat mass, may be associated with increased odds ratio of positional OSA compared with non-positional OSA.
PURPOSE: Body composition is considered to be associated with obstructive sleep apnea (OSA) severity. This cross-sectional study aimed to examine associations of overnight body composition changes with positional OSA. METHODS: The body composition of patients diagnosed with non-positional and positional OSA was measured before and after overnight polysomnography. Odds ratios (ORs) of outcome variables between the case (positional OSA) and reference (non-positional OSA) groups were examined for associations with sleep-related parameters and with changes in body composition by a logistic regression analysis. RESULTS: Among 1584 patients with OSA, we used 1056 patients with non-positional OSA as the reference group. We found that a 1-unit increase in overnight changes of total fat percentage and total fat mass were associated with 1.076-fold increased OR (95% confidence interval (CI): 1.014, 1.142) and 1.096-fold increased OR (95% CI: 1.010, 1.189) of positional OSA, respectively (all p < 0.05). Additionally, a 1-unit increase in overnight changes of lower limb fat percentage and upper limb fat mass were associated with 1.043-fold increased OR (95% CI: 1.004, 1.084) and 2.638-fold increased OR (95% CI: 1.313, 5.302) of positional OSA, respectively (all p < 0.05). We observed that a 1-unit increase in overnight changes of trunk fat percentage and trunk fat mass were associated with 1.056-fold increased OR (95% CI: 1.008, 1.106) and 1.150-fold increased OR (95% CI: 1.016, 1.301) of positional OSA, respectively (all p < 0.05). CONCLUSION: Our findings indicated that nocturnal changes in the body's composition, especially total fat mass, total fat percentage, lower limb fat percentage, upper limb fat mass, trunk fat percentage, and trunk fat mass, may be associated with increased odds ratio of positional OSA compared with non-positional OSA.
Authors: James J Bignold; Jeremy D Mercer; Nick A Antic; R Doug McEvoy; Peter G Catcheside Journal: J Clin Sleep Med Date: 2011-08-15 Impact factor: 4.062
Authors: Dana L Duren; Richard J Sherwood; Stefan A Czerwinski; Miryoung Lee; Audrey C Choh; Roger M Siervogel; Wm Cameron Chumlea Journal: J Diabetes Sci Technol Date: 2008-11