Literature DB >> 3573995

Platelet changes after a saturated fat meal and their prevention by Dazmegrel, a thromboxane synthetase inhibitor.

J J Belch, A R Saniabadi, K McLaughlin, C D Forbes.   

Abstract

A saturated fat meal was given to 10 normal males both before and after pretreatment with UK38,485, a thromboxane synthetase inhibitor (Dazmegrel, Pfizer Central Research, Sandwich, Kent, United Kingdom). Following the fat meal at 2 and 4 hr there was laboratory evidence of platelet activation. Dazmegrel lowered baseline platelet activity and lessened platelet activation following the fat meal. This drug should be investigated further as a potential antithrombotic agent.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 3573995     DOI： 10.1007/bf02537296

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  16 in total

1.  [STUDIES ON BLOOD PLATELET AGGLUTINATION FOLLOWING THE ADMINISTRATION OF VARIOUS DIETARY FATS].

Authors:  E BOEHLE; J BAUKE; E HARMUTH; K BREDDIN
Journal:  Klin Wochenschr       Date:  1965-05-15

2.  Aggregation of blood platelets by adenosine diphosphate and its reversal.

Authors:  G V BORN
Journal:  Nature       Date:  1962-06-09       Impact factor: 49.962

3.  Myocardial blood flow and oxygen consumption during postprandial lipemia and heparin-induced lipolysis.

Authors:  T J REGAN; K BINAK; S GORDON; V DEFAZIO; H K HELLEMS
Journal:  Circulation       Date:  1961-01       Impact factor: 29.690

4.  Angina pectoris induced by fat ingestion in patients with coronary artery disease; ballistocardiographic and electrocardiographic findings.

Authors:  P T KUO; C R JOYNER
Journal:  J Am Med Assoc       Date:  1955-07-23

5.  [Rapid physiological coagulation method in determination of fibrinogen].

Authors:  A CLAUSS
Journal:  Acta Haematol       Date:  1957-04       Impact factor: 2.195

6.  Effect of feeding fat on fibrinolysis, Stypven time, and platelet aggregation in Africans, Asians, and Europeans.

Authors:  J C Ferguson; N Mackay; G P McNicol
Journal:  J Clin Pathol       Date:  1970-10       Impact factor: 3.411

7.  Induction of circulating platelet-aggregates in healthy subjects by a saturated fat meal.

Authors:  G D Lowe; R V Johnston; M M Drummond; C D Forbes; C R Prentice
Journal:  Thromb Res       Date:  1979       Impact factor: 3.944

8.  Platelet function and platelet phospholipids in patients with hyperbetalipoproteinemia. Effect of nicotinic acid and clofibrate.

Authors:  A Nordoy; J M Rodset
Journal:  Acta Med Scand       Date:  1971-05

9.  Prevention of lipid induced platelet aggregation by aspirin.

Authors:  R V Johnston; J V Giner; G D Lowe; C D Forbes; C R Prentice
Journal:  Thromb Res       Date:  1982-07-15       Impact factor: 3.944

10.  The effect of fat feeding on fibrinolysis, "Stypven" time and platelet aggregation.

Authors:  A H Dubber; B Rifkind; M Gale; G P McNicol; A S Douglas
Journal:  J Atheroscler Res       Date:  1967 Mar-Apr
View more
  2 in total

1.  Abnormal plasma fibrinolysis in patients with rheumatoid arthritis and impaired endothelial fibrinolytic response in those complicated by vasculitis.

Authors:  C S Lau; M McLaren; J Hanslip; M Kerr; J J Belch
Journal:  Ann Rheum Dis       Date:  1993-09       Impact factor: 19.103

2.  Platelet function in the postprandial period.

Authors:  Helmut Sinzinger; Robert Berent
Journal:  Thromb J       Date:  2012-09-03
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.