BACKGROUND: Perioperative systemic inflammation affects the long-term oncological outcomes of patients with malignancies. We evaluated the clinical impact of the preoperative platelet-to-lymphocyte ratio (PLR) in patients with resectable esophageal cancer who received curative treatment. PATIENTS AND METHODS: This study included 168 patients who underwent curative surgery followed by perioperative adjuvant chemotherapy for esophageal cancer between 2005 and 2018. The risk factors for overall survival (OS) and recurrence-free survival (RFS) were identified. RESULTS: Based on the 3- and 5-year OS rates, we set the cut-off value of the PLR at 150 in the present study. Among 168 patients, 78 patients (46.4%) were categorized into the PLR-low group and 90 patients (53.6%) were categorized into the PLR-high group. The 3- and 5-year OS rates were 64.4% and 53.8%, respectively, in the PLR-low group, and 46.9% and 38.1% in the PLR-high group; the difference in OS was significant (p=0.046). PLR was therefore selected for the final multivariate analysis model (hazard ratio=1.553, 95% confidence interval=1.026-2.350, p=0.037). When the perioperative clinical course was compared between the two groups, the incidence of grade 2 or more anastomotic leakage after surgery was significantly lower in the PLR-low group at 26.9% compared to 43.3% in the PLR-high group (p=0.027). CONCLUSION: The PLR had a clinical impact on the long-term oncological outcomes of patients with esophageal cancer treated with curative intent. Therefore, the PLR might be a promising prognostic factor for patients with esophageal cancer.
BACKGROUND: Perioperative systemic inflammation affects the long-term oncological outcomes of patients with malignancies. We evaluated the clinical impact of the preoperative platelet-to-lymphocyte ratio (PLR) in patients with resectable esophageal cancer who received curative treatment. PATIENTS AND METHODS: This study included 168 patients who underwent curative surgery followed by perioperative adjuvant chemotherapy for esophageal cancer between 2005 and 2018. The risk factors for overall survival (OS) and recurrence-free survival (RFS) were identified. RESULTS: Based on the 3- and 5-year OS rates, we set the cut-off value of the PLR at 150 in the present study. Among 168 patients, 78 patients (46.4%) were categorized into the PLR-low group and 90 patients (53.6%) were categorized into the PLR-high group. The 3- and 5-year OS rates were 64.4% and 53.8%, respectively, in the PLR-low group, and 46.9% and 38.1% in the PLR-high group; the difference in OS was significant (p=0.046). PLR was therefore selected for the final multivariate analysis model (hazard ratio=1.553, 95% confidence interval=1.026-2.350, p=0.037). When the perioperative clinical course was compared between the two groups, the incidence of grade 2 or more anastomotic leakage after surgery was significantly lower in the PLR-low group at 26.9% compared to 43.3% in the PLR-high group (p=0.027). CONCLUSION: The PLR had a clinical impact on the long-term oncological outcomes of patients with esophageal cancer treated with curative intent. Therefore, the PLR might be a promising prognostic factor for patients with esophageal cancer.
Authors: K Muro; F Lordick; T Tsushima; G Pentheroudakis; E Baba; Z Lu; B C Cho; I M Nor; M Ng; L-T Chen; K Kato; J Li; M-H Ryu; W I Wan Zamaniah; W-P Yong; K-H Yeh; T E Nakajima; K Shitara; H Kawakami; Y Narita; T Yoshino; E Van Cutsem; E Martinelli; E C Smyth; D Arnold; H Minami; J Tabernero; J-Y Douillard Journal: Ann Oncol Date: 2019-01-01 Impact factor: 32.976
Authors: Yuichiro Doki; Jaffer A Ajani; Ken Kato; Jianming Xu; Lucjan Wyrwicz; Satoru Motoyama; Takashi Ogata; Hisato Kawakami; Chih-Hung Hsu; Antoine Adenis; Farid El Hajbi; Maria Di Bartolomeo; Maria I Braghiroli; Eva Holtved; Sandra A Ostoich; Hye R Kim; Masaki Ueno; Wasat Mansoor; Wen-Chi Yang; Tianshu Liu; John Bridgewater; Tomoki Makino; Ioannis Xynos; Xuan Liu; Ming Lei; Kaoru Kondo; Apurva Patel; Joseph Gricar; Ian Chau; Yuko Kitagawa Journal: N Engl J Med Date: 2022-02-03 Impact factor: 176.079