Dirk Rades1, Britta Warwas2, Karsten Gerull2, Ralph Pries3, Anke Leichtle3, Karl L Bruchhage3, Samer G Hakim4, Steven E Schild5, Florian Cremers2. 1. Departments of Radiation Oncology, University of Lübeck, Lübeck, Germany; dirk.rades@uksh.de. 2. Departments of Radiation Oncology, University of Lübeck, Lübeck, Germany. 3. Oto-Rhino-Laryngology and Head and Neck Surgery, and University of Lübeck, Lübeck, Germany. 4. Oral and Maxillofacial Surgery, University of Lübeck, Lübeck, Germany. 5. Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ, U.S.A.
Abstract
BACKGROUND/AIM: Radiotherapy of head-and-neck cancers can cause xerostomia. This study investigated potential prognostic factors for complete recovery from this complication. PATIENTS AND METHODS: Eighty head-and-neck cancer patients with radiation-induced xerostomia were retrospectively evaluated. Thirteen characteristics were analyzed for complete recovery (to grade 0) from xerostomia including age, sex, tumor site and stage, nodal stage, upfront surgery, mean dose to ipsilateral, contralateral and both parotid glands, chemotherapy, radiation type and dose, and initial grade of xerostomia. RESULTS: Fifteen patients (18.8%) experienced complete recovery of xerostomia. Significant associations with complete recovery were found for initial grade 1 xerostomia (p<0.001), mean dose to contralateral parotid gland of <20 Gy (p=0.034), and radiation treatment without chemotherapy (p=0.047). CONCLUSION: Almost every fifth patient experienced complete recovery of xerostomia. Prognostic factors were identified that can guide radiation oncologists during the process of treatment planning.
BACKGROUND/AIM: Radiotherapy of head-and-neck cancers can cause xerostomia. This study investigated potential prognostic factors for complete recovery from this complication. PATIENTS AND METHODS: Eighty head-and-neck cancer patients with radiation-induced xerostomia were retrospectively evaluated. Thirteen characteristics were analyzed for complete recovery (to grade 0) from xerostomia including age, sex, tumor site and stage, nodal stage, upfront surgery, mean dose to ipsilateral, contralateral and both parotid glands, chemotherapy, radiation type and dose, and initial grade of xerostomia. RESULTS: Fifteen patients (18.8%) experienced complete recovery of xerostomia. Significant associations with complete recovery were found for initial grade 1 xerostomia (p<0.001), mean dose to contralateral parotid gland of <20 Gy (p=0.034), and radiation treatment without chemotherapy (p=0.047). CONCLUSION: Almost every fifth patient experienced complete recovery of xerostomia. Prognostic factors were identified that can guide radiation oncologists during the process of treatment planning.
Authors: Angel I Blanco; K S Clifford Chao; Issam El Naqa; Gregg E Franklin; Konstantin Zakarian; Milos Vicic; Joseph O Deasy Journal: Int J Radiat Oncol Biol Phys Date: 2005-07-15 Impact factor: 7.038
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Authors: Aline Lima da Silva Deboni; Adelmo José Giordani; Nilza Nelly Fontana Lopes; Rodrigo Souza Dias; Roberto Araujo Segreto; Siri Beier Jensen; Helena Regina Comodo Segreto Journal: Support Care Cancer Date: 2012-03-13 Impact factor: 3.603
Authors: Britta Warwas; Florian Cremers; Karsten Gerull; Anke Leichtle; Karl L Bruchhage; Samer G Hakim; Steven E Schild; Dirk Rades Journal: Anticancer Res Date: 2022-05 Impact factor: 2.480
Authors: Michael K M Kam; Sing-Fai Leung; Benny Zee; Ricky M C Chau; Joyce J S Suen; Frankie Mo; Maria Lai; Rosalie Ho; Kin-yin Cheung; Brian K H Yu; Samuel K W Chiu; Peter H K Choi; Peter M L Teo; Wing-hong Kwan; Anthony T C Chan Journal: J Clin Oncol Date: 2007-11-01 Impact factor: 44.544
Authors: Anne S McMillan; Edmond H N Pow; Dora L W Kwong; May C M Wong; Jonathan S T Sham; Lucullus H T Leung; W Keung Leung Journal: Head Neck Date: 2006-08 Impact factor: 3.147