Literature DB >> 35736814

Shining a FLASHlight on Ultrahigh Dose-Rate Radiation and Possible Late Toxicity.

Amit Maity1,2,3, Constantinos Koumenis1.   

Abstract

A recent study reported results from a clinical trial in cats and from experiments in mini-pigs in which a single dose of radiotherapy was delivered at ultrahigh dose rates (FLASH). There was acceptable acute toxicity; however, some animals suffered severe late toxicity, raising caution in the design of future trials. See related article by Rohrer Bley et al., p. 3814. ©2022 American Association for Cancer Research.

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Year:  2022        PMID： 35736814      PMCID： PMC9444945          DOI： 10.1158/1078-0432.CCR-22-1255

Source DB:  PubMed          Journal:  Clin Cancer Res        ISSN： 1078-0432            Impact factor:   13.801


  18 in total

1.  Long-term neurocognitive benefits of FLASH radiotherapy driven by reduced reactive oxygen species.

Authors:  Pierre Montay-Gruel; Munjal M Acharya; Kristoffer Petersson; Leila Alikhani; Chakradhar Yakkala; Barrett D Allen; Jonathan Ollivier; Benoit Petit; Patrik Gonçalves Jorge; Amber R Syage; Thuan A Nguyen; Al Anoud D Baddour; Celine Lu; Paramvir Singh; Raphael Moeckli; François Bochud; Jean-François Germond; Pascal Froidevaux; Claude Bailat; Jean Bourhis; Marie-Catherine Vozenin; Charles L Limoli
Journal:  Proc Natl Acad Sci U S A       Date:  2019-05-16       Impact factor: 11.205

2.  FLASH Radiation Therapy: New Technology Plus Biology Required.

Authors:  Jeffrey C Buchsbaum; C Norman Coleman; Michael G Espey; Pataje G S Prasanna; Jacek Capala; Mansoor M Ahmed; Julie A Hong; Ceferino Obcemea
Journal:  Int J Radiat Oncol Biol Phys       Date:  2021-02-03       Impact factor: 7.038

3.  Design, Implementation, and in Vivo Validation of a Novel Proton FLASH Radiation Therapy System.

Authors:  Eric S Diffenderfer; Ioannis I Verginadis; Michele M Kim; Khayrullo Shoniyozov; Anastasia Velalopoulou; Denisa Goia; Mary Putt; Sarah Hagan; Stephen Avery; Kevin Teo; Wei Zou; Alexander Lin; Samuel Swisher-McClure; Cameron Koch; Ann R Kennedy; Andy Minn; Amit Maity; Theresa M Busch; Lei Dong; Costas Koumenis; James Metz; Keith A Cengel
Journal:  Int J Radiat Oncol Biol Phys       Date:  2020-02-01       Impact factor: 7.038

4.  FLASH Investigations Using Protons: Design of Delivery System, Preclinical Setup and Confirmation of FLASH Effect with Protons in Animal Systems.

Authors:  Qixian Zhang; Ethan Cascio; Chengming Li; Qingyuan Yang; Leo E Gerweck; Peigen Huang; Bernard Gottschalk; Jacob Flanz; Jan Schuemann
Journal:  Radiat Res       Date:  2020-12-01       Impact factor: 2.841

5.  The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients.

Authors:  Marie-Catherine Vozenin; Pauline De Fornel; Kristoffer Petersson; Patrick Devauchelle; Jean Bourhis; Vincent Favaudon; Maud Jaccard; Jean-François Germond; Benoit Petit; Marco Burki; Gisèle Ferrand; David Patin; Hanan Bouchaab; Mahmut Ozsahin; François Bochud; Claude Bailat
Journal:  Clin Cancer Res       Date:  2018-06-06       Impact factor: 12.531

Review 6.  Biological Benefits of Ultra-high Dose Rate FLASH Radiotherapy: Sleeping Beauty Awoken.

Authors:  M-C Vozenin; J H Hendry; C L Limoli
Journal:  Clin Oncol (R Coll Radiol)       Date:  2019-04-19       Impact factor: 4.126

7.  Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice.

Authors:  Vincent Favaudon; Laura Caplier; Virginie Monceau; Frédéric Pouzoulet; Mano Sayarath; Charles Fouillade; Marie-France Poupon; Isabel Brito; Philippe Hupé; Jean Bourhis; Janet Hall; Jean-Jacques Fontaine; Marie-Catherine Vozenin
Journal:  Sci Transl Med       Date:  2014-07-16       Impact factor: 17.956

8.  Hypofractionated FLASH-RT as an Effective Treatment against Glioblastoma that Reduces Neurocognitive Side Effects in Mice.

Authors:  Pierre Montay-Gruel; Munjal M Acharya; Charles L Limoli; Marie-Catherine Vozenin; Patrik Gonçalves Jorge; Benoît Petit; Ioannis G Petridis; Philippe Fuchs; Ron Leavitt; Kristoffer Petersson; Maude Gondré; Jonathan Ollivier; Raphael Moeckli; François Bochud; Claude Bailat; Jean Bourhis; Jean-François Germond
Journal:  Clin Cancer Res       Date:  2020-10-15       Impact factor: 13.801

9.  Abdominal FLASH irradiation reduces radiation-induced gastrointestinal toxicity for the treatment of ovarian cancer in mice.

Authors:  Karen Levy; Suchitra Natarajan; Jinghui Wang; Stephanie Chow; Joshua T Eggold; Phoebe E Loo; Rakesh Manjappa; Stavros Melemenidis; Frederick M Lartey; Emil Schüler; Lawrie Skinner; Marjan Rafat; Ryan Ko; Anna Kim; Duaa H Al-Rawi; Rie von Eyben; Oliver Dorigo; Kerriann M Casey; Edward E Graves; Karl Bush; Amy S Yu; Albert C Koong; Peter G Maxim; Billy W Loo; Erinn B Rankin
Journal:  Sci Rep       Date:  2020-12-10       Impact factor: 4.379

Review 10.  A roadmap to clinical trials for FLASH.

Authors:  Paige A Taylor; Jean M Moran; David A Jaffray; Jeffrey C Buchsbaum
Journal:  Med Phys       Date:  2022-04-25       Impact factor: 4.506
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