Eduardo David Piemonte1, Jerónimo Pablo Lazos2, Gerardo Marcelo Gilligan2, René Luis Panico2, Laura Cecilia Werner3, Yi-Hsin Yang4, Saman Warnakulasuriya5. 1. Oral Medicine Department, Dentistry College, Universidad Nacional de Córdoba, Av. Haya de la Torre s/n, Ciudad Universitaria, 5000, Córdoba, Argentina. eduardo.piemonte@unc.edu.ar. 2. Oral Medicine Department, Dentistry College, Universidad Nacional de Córdoba, Av. Haya de la Torre s/n, Ciudad Universitaria, 5000, Córdoba, Argentina. 3. Oral Medicine Service, Hospital Alemán, Buenos Aires, Argentina. 4. National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan. 5. Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London & WHO Collaborating Centre for Oral Cancer, London, UK.
Abstract
OBJECTIVES: Oral squamous cell carcinoma (OSCC) is a multifactorial disease. The individual effect of each risk factor for OSCC may be conditioned by the frequency of other factors. The objective of this study was to identify the association between chronic mechanical irritation (CMI) and OSCC and to analyse the influence of CMI on other important risk factors for OSCC. MATERIALS AND METHODS: A prospective and age/sex-matched case-control study was performed in two institutions from Argentina between 2009 and 2019, with consecutive and newly diagnosed OSCC. The frequencies of tobacco, alcohol, and CMI were analysed using conditional logistic regression. Cumulative tobacco consumption and the presence of CMI were analysed using the Mann-Whitney test. RESULTS: CMI and OSCC were associated with an OR of 7.02 (95% CI 3.57-13.78, p < 0.001). The combination of CMI and alcohol demonstrated the highest risk of OSCC (OR 53.83, CI 95% 8.04-360, p < 0.0001), followed by the combination of CMI, tobacco, and alcohol (OR 48.06, CI 95% 8.47-272, p < 0.0001). The combination of CMI and tobacco was also significant (OR 5.61, CI 95% 1.07-29.54, p = 0.042). Patients with CMI developed OSCC with less cumulative tobacco use compared with those without CMI. CONCLUSION: CMI is an independent risk factor for OSCC, and it could act as a risk modifier among tobacco and alcohol users having an enhancing effect. CLINICAL RELEVANCE: Elimination of CMI could decrease the risk of OSCC.
OBJECTIVES: Oral squamous cell carcinoma (OSCC) is a multifactorial disease. The individual effect of each risk factor for OSCC may be conditioned by the frequency of other factors. The objective of this study was to identify the association between chronic mechanical irritation (CMI) and OSCC and to analyse the influence of CMI on other important risk factors for OSCC. MATERIALS AND METHODS: A prospective and age/sex-matched case-control study was performed in two institutions from Argentina between 2009 and 2019, with consecutive and newly diagnosed OSCC. The frequencies of tobacco, alcohol, and CMI were analysed using conditional logistic regression. Cumulative tobacco consumption and the presence of CMI were analysed using the Mann-Whitney test. RESULTS: CMI and OSCC were associated with an OR of 7.02 (95% CI 3.57-13.78, p < 0.001). The combination of CMI and alcohol demonstrated the highest risk of OSCC (OR 53.83, CI 95% 8.04-360, p < 0.0001), followed by the combination of CMI, tobacco, and alcohol (OR 48.06, CI 95% 8.47-272, p < 0.0001). The combination of CMI and tobacco was also significant (OR 5.61, CI 95% 1.07-29.54, p = 0.042). Patients with CMI developed OSCC with less cumulative tobacco use compared with those without CMI. CONCLUSION: CMI is an independent risk factor for OSCC, and it could act as a risk modifier among tobacco and alcohol users having an enhancing effect. CLINICAL RELEVANCE: Elimination of CMI could decrease the risk of OSCC.
Authors: Gioia Di Credico; Valeria Edefonti; Jerry Polesel; Francesco Pauli; Nicola Torelli; Diego Serraino; Eva Negri; Daniele Luce; Isabelle Stucker; Keitaro Matsuo; Paul Brennan; Marta Vilensky; Leticia Fernandez; Maria Paula Curado; Ana Menezes; Alexander W Daudt; Rosalina Koifman; Victor Wunsch-Filho; Ivana Holcatova; Wolfgang Ahrens; Pagona Lagiou; Lorenzo Simonato; Lorenzo Richiardi; Claire Healy; Kristina Kjaerheim; David I Conway; Tatiana V Macfarlane; Peter Thomson; Antonio Agudo; Ariana Znaor; Leonardo F Boaventura Rios; Tatiana N Toporcov; Silvia Franceschi; Rolando Herrero; Joshua Muscat; Andrew F Olshan; Jose P Zevallos; Carlo La Vecchia; Deborah M Winn; Erich M Sturgis; Guojun Li; Eleonora Fabianova; Jolanda Lissowska; Dana Mates; Peter Rudnai; Oxana Shangina; Beata Swiatkowska; Kirsten Moysich; Zuo-Feng Zhang; Hal Morgenstern; Fabio Levi; Elaine Smith; Philip Lazarus; Cristina Bosetti; Werner Garavello; Karl Kelsey; Michael McClean; Heribert Ramroth; Chu Chen; Stephen M Schwartz; Thomas L Vaughan; Tongzhang Zheng; Gwenn Menvielle; Stefania Boccia; Gabriella Cadoni; Richard B Hayes; Mark Purdue; Maura Gillison; Stimson Schantz; Guo-Pei Yu; Hermann Brenner; Gypsyamber D'Souza; Neil D Gross; Shu-Chun Chuang; Paolo Boffetta; Mia Hashibe; Yuan-Chin Amy Lee; Luigino Dal Maso Journal: Oral Oncol Date: 2019-05-17 Impact factor: 5.337
Authors: Kivanc Bektas-Kayhan; Gizem Karagoz; Mustafa Caner Kesimli; Ahmet Nafiz Karadeniz; Rasim Meral; Musa Altun; Meral Unur Journal: Asian Pac J Cancer Prev Date: 2014
Authors: Gabriela Fürst Vaccarezza; José Leopoldo Ferreira Antunes; Pedro Michaluart-Júnior Journal: J Public Health Dent Date: 2010 Impact factor: 1.821