BACKGROUND: Oral chronic traumatic ulcer (CTU) is caused by constant irritation by dental edges or restorations and could behave as a pre-malignant lesion in a field initiated by carcinogens such as tobacco or alcohol. METHODS: We developed an experimental model in the hamster cheek pouch, combining the chemical carcinogen 7,12-dimethyl-benzanthracene (DMBA) with CTU. RESULTS: The successive or simultaneous action of both agents induced a significantly larger number of endophytic carcinomas than larger doses of DMBA alone. CTU alone failed to induce tumor development. Ploidy analysis revealed significantly higher malignancy indices in endophytic than in exophytic carcinomas. 5-Bromo-2-deoxyuridine labeling evidenced greater proliferation around the ulcers in chemically cancerized epithelium than around ulcers in healthy epithelium. CONCLUSIONS: The results show that CTU acts as a tumor promoter in this model. This finding is clinically relevant in that CTU may increase the risk of malignant transformation in patients with subclinical tumor initiation.
BACKGROUND: Oral chronic traumatic ulcer (CTU) is caused by constant irritation by dental edges or restorations and could behave as a pre-malignant lesion in a field initiated by carcinogens such as tobacco or alcohol. METHODS: We developed an experimental model in the hamster cheek pouch, combining the chemical carcinogen 7,12-dimethyl-benzanthracene (DMBA) with CTU. RESULTS: The successive or simultaneous action of both agents induced a significantly larger number of endophytic carcinomas than larger doses of DMBA alone. CTU alone failed to induce tumor development. Ploidy analysis revealed significantly higher malignancy indices in endophytic than in exophytic carcinomas. 5-Bromo-2-deoxyuridine labeling evidenced greater proliferation around the ulcers in chemically cancerized epithelium than around ulcers in healthy epithelium. CONCLUSIONS: The results show that CTU acts as a tumor promoter in this model. This finding is clinically relevant in that CTU may increase the risk of malignant transformation in patients with subclinical tumor initiation.
Authors: Elisa M Heber; M Frederick Hawthorne; Peter J Kueffer; Marcela A Garabalino; Silvia I Thorp; Emiliano C C Pozzi; Andrea Monti Hughes; Charles A Maitz; Satish S Jalisatgi; David W Nigg; Paula Curotto; Verónica A Trivillin; Amanda E Schwint Journal: Proc Natl Acad Sci U S A Date: 2014-10-27 Impact factor: 11.205
Authors: Andrea Monti Hughes; Juan Longhino; Esteban Boggio; Vanina A Medina; Diego J Martinel Lamas; Marcela A Garabalino; Elisa M Heber; Emiliano C C Pozzi; María E Itoiz; Romina F Aromando; David W Nigg; Verónica A Trivillin; Amanda E Schwint Journal: Radiat Environ Biophys Date: 2017-09-04 Impact factor: 1.925
Authors: Eduardo David Piemonte; Jerónimo Pablo Lazos; Gerardo Marcelo Gilligan; René Luis Panico; Laura Cecilia Werner; Yi-Hsin Yang; Saman Warnakulasuriya Journal: Clin Oral Investig Date: 2022-06-21 Impact factor: 3.606