Evelyn S Qin1, Laura S Gold2, Namrata Singh3, Katherine D Wysham3,4, Catherine L Hough5, Payal B Patel6, Aaron E Bunnell1, James S Andrews3. 1. Department of Rehabilitation Medicine, University of Washington, Seattle, Washington, USA. 2. Department of Radiology, University of Washington, Seattle, Washington, USA. 3. Department of Medicine, University of Washington, Seattle, Washington, USA. 4. VA Puget Sound Health Care System, Seattle, Washington, USA. 5. Department of Medicine, Oregon Health & Science University, Oregon, Portland, USA. 6. Department of Neurology, University of Washington, Seattle, Washington, USA.
Abstract
INTRODUCTION: There are an increasing number of individuals with long-term symptoms of coronavirus-19 disease (COVID-19); however, the prognosis for recovery of physical function and fatigue after COVID-19 is uncertain. OBJECTIVE: To report the changes in functional recovery between 1 and 6 months after hospitalization of adults hospitalized for COVID-19 and explore the baseline factors associated with physical function recovery. DESIGN: A prospective cohort study. SETTING: Tertiary care hospital. PARTICIPANTS: U.S. adult COVID-19 survivors. INTERVENTION: N/A. MAIN OUTCOME MEASURES: Telephone interviews assessed three outcome domains: basic and instrumental activities of daily living (ADLs) performance, fatigue, and general physical function (Health Assessment Questionnaire [HAQ]). RESULTS: The age of participants (n = 92) ranged from 22 to 95 years (54.3 ± 17.2). Across outcome domains, a majority (63%-67%) of participants developed new ADL impairment, fatigue, or worsening HAQ severity by 1 month. Of those, 50%-79% partially or fully recovered by 6 months, but 21%-50% did not recover at least partially. Fifteen to 30% developed new impairment between 1 and 6 months. For those without any improvement in ADL impairments at 6 months, lower socioeconomic status was significantly more common (p = .01) and age ≥ 65 (p = .06), trending toward being more common. CONCLUSION: In this cohort, a substantial proportion of the participants who developed new ADL impairment, worsening fatigue, or HAQ severity after hospitalization for COVID-19 did not recover at least partially by 6 months after discharge. Evaluating functional status 1 month after discharge may be important in understanding functional prognosis and recovery after hospitalization for COVID-19.
INTRODUCTION: There are an increasing number of individuals with long-term symptoms of coronavirus-19 disease (COVID-19); however, the prognosis for recovery of physical function and fatigue after COVID-19 is uncertain. OBJECTIVE: To report the changes in functional recovery between 1 and 6 months after hospitalization of adults hospitalized for COVID-19 and explore the baseline factors associated with physical function recovery. DESIGN: A prospective cohort study. SETTING: Tertiary care hospital. PARTICIPANTS: U.S. adult COVID-19 survivors. INTERVENTION: N/A. MAIN OUTCOME MEASURES: Telephone interviews assessed three outcome domains: basic and instrumental activities of daily living (ADLs) performance, fatigue, and general physical function (Health Assessment Questionnaire [HAQ]). RESULTS: The age of participants (n = 92) ranged from 22 to 95 years (54.3 ± 17.2). Across outcome domains, a majority (63%-67%) of participants developed new ADL impairment, fatigue, or worsening HAQ severity by 1 month. Of those, 50%-79% partially or fully recovered by 6 months, but 21%-50% did not recover at least partially. Fifteen to 30% developed new impairment between 1 and 6 months. For those without any improvement in ADL impairments at 6 months, lower socioeconomic status was significantly more common (p = .01) and age ≥ 65 (p = .06), trending toward being more common. CONCLUSION: In this cohort, a substantial proportion of the participants who developed new ADL impairment, worsening fatigue, or HAQ severity after hospitalization for COVID-19 did not recover at least partially by 6 months after discharge. Evaluating functional status 1 month after discharge may be important in understanding functional prognosis and recovery after hospitalization for COVID-19.
Authors: Evelyn S Qin; Laura S Gold; Catherine L Hough; Patricia P Katz; Aaron E Bunnell; Katherine D Wysham; James S Andrews Journal: PM R Date: 2021-11-03 Impact factor: 2.218
Authors: Evelyn S Qin; Laura S Gold; Namrata Singh; Katherine D Wysham; Catherine L Hough; Payal B Patel; Aaron E Bunnell; James S Andrews Journal: PM R Date: 2022-06-21 Impact factor: 2.218
Authors: Vineet Chopra; Scott A Flanders; Megan O'Malley; Anurag N Malani; Hallie C Prescott Journal: Ann Intern Med Date: 2020-11-11 Impact factor: 25.391
Authors: Evelyn S Qin; Laura S Gold; Namrata Singh; Katherine D Wysham; Catherine L Hough; Payal B Patel; Aaron E Bunnell; James S Andrews Journal: PM R Date: 2022-06-21 Impact factor: 2.218