Roberta Pineda1,2,3,4,5, Lara Liszka6,7, Pido Tran6, Jenny Kwon6,8, Terrie Inder9. 1. Program in Occupational Therapy, Washington University School of Medicine, St. Louis, MO, USA. bobbi.pineda@chan.usc.edu. 2. Chan Division of Occupational Science and Occupational Therapy, University of Southern California, Los Angeles, CA, USA. bobbi.pineda@chan.usc.edu. 3. Department of Pediatrics, Keck School of Medicine, Los Angeles, CA, USA. bobbi.pineda@chan.usc.edu. 4. Gehr Family Center for Health Systems Science and Innovation, University of Southern California, Los Angeles, CA, USA. bobbi.pineda@chan.usc.edu. 5. Center for the Changing Family, University of Southern California, Los Angeles, CA, USA. bobbi.pineda@chan.usc.edu. 6. Program in Occupational Therapy, Washington University School of Medicine, St. Louis, MO, USA. 7. Department of Physical and Occupational Therapy, Duke University Health System, Durham, NC, USA. 8. Chan Division of Occupational Science and Occupational Therapy, University of Southern California, Los Angeles, CA, USA. 9. Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Abstract
OBJECTIVE: To describe differences in neurobehavior among very preterm infants with low medical risk at term equivalent age and full-term infants. STUDY DESIGN: One-hundred eighty-six (136 infants born ≤32 weeks gestation with low medical risk at term equivalent age and 50 full-term infants within 4 days of birth) had standardized neurobehavioral assessments. Low medical risk was defined by ventilation <10 days and absence of significant brain injury, necrotizing enterocolitis, patent ductus arteriosus, and retinopathy of prematurity. RESULTS: Very preterm infants with low medical risk at term equivalent age demonstrated more sub-optimal reflexes (p < 0.001; ß = 1.53) and more stress (p < 0.001; ß = 0.08) on the NICU Network Neurobehavioral Scale compared to their full-term counterparts. Very preterm infants with low medical risk also performed worse on the Hammersmith Neonatal Neurological Examination (p = 0.005; ß = -3.4). CONCLUSION: Very preterm infants at term equivalent age continue to demonstrate less optimal neurobehavior compared to full-term infants.
OBJECTIVE: To describe differences in neurobehavior among very preterm infants with low medical risk at term equivalent age and full-term infants. STUDY DESIGN: One-hundred eighty-six (136 infants born ≤32 weeks gestation with low medical risk at term equivalent age and 50 full-term infants within 4 days of birth) had standardized neurobehavioral assessments. Low medical risk was defined by ventilation <10 days and absence of significant brain injury, necrotizing enterocolitis, patent ductus arteriosus, and retinopathy of prematurity. RESULTS: Very preterm infants with low medical risk at term equivalent age demonstrated more sub-optimal reflexes (p < 0.001; ß = 1.53) and more stress (p < 0.001; ß = 0.08) on the NICU Network Neurobehavioral Scale compared to their full-term counterparts. Very preterm infants with low medical risk also performed worse on the Hammersmith Neonatal Neurological Examination (p = 0.005; ß = -3.4). CONCLUSION: Very preterm infants at term equivalent age continue to demonstrate less optimal neurobehavior compared to full-term infants.
Authors: Jeanie L Cheong; Lex W Doyle; Alice C Burnett; Katherine J Lee; Jennifer M Walsh; Cody R Potter; Karli Treyvaud; Deanne K Thompson; Joy E Olsen; Peter J Anderson; Alicia J Spittle Journal: JAMA Pediatr Date: 2017-04-03 Impact factor: 16.193