Literature DB >> 35707820

Optimal partitioning for the proportional hazards model.

Usha Govindarajulu1, Thaddeus Tarpey2.   

Abstract

This paper discusses methods for clustering a continuous covariate in a survival analysis model. The advantages of using a categorical covariate defined from discretizing a continuous covariate (via clustering) is (i) enhanced interpretability of the covariate's impact on survival and (ii) relaxing model assumptions that are usually required for survival models, such as the proportional hazards model. Simulations and an example are provided to illustrate the methods.
© 2020 Informa UK Limited, trading as Taylor & Francis Group.

Entities:  

Keywords:  Clustering; discretize; moderator analysis; stratification; survival analysis

Year:  2020        PMID: 35707820      PMCID: PMC9041949          DOI: 10.1080/02664763.2020.1846690

Source DB:  PubMed          Journal:  J Appl Stat        ISSN: 0266-4763            Impact factor:   1.416


  17 in total

1.  Optimal choice of a cut point for a quantitative diagnostic test performed for research purposes.

Authors:  Laurence S Magder; Alan D Fix
Journal:  J Clin Epidemiol       Date:  2003-10       Impact factor: 6.437

2.  Confidence intervals for the effect of a prognostic factor after selection of an 'optimal' cutpoint.

Authors:  Norbert Holländer; Willi Sauerbrei; Martin Schumacher
Journal:  Stat Med       Date:  2004-06-15       Impact factor: 2.373

Review 3.  The cost of dichotomising continuous variables.

Authors:  Douglas G Altman; Patrick Royston
Journal:  BMJ       Date:  2006-05-06

4.  Use of pattern analysis to predict differential relapse of remitted patients with major depression during 1 year of treatment with fluoxetine or placebo.

Authors:  J W Stewart; F M Quitkin; P J McGrath; J Amsterdam; M Fava; J Fawcett; F Reimherr; J Rosenbaum; C Beasley; P Roback
Journal:  Arch Gen Psychiatry       Date:  1998-04

Review 5.  Dangers of using "optimal" cutpoints in the evaluation of prognostic factors.

Authors:  D G Altman; B Lausen; W Sauerbrei; M Schumacher
Journal:  J Natl Cancer Inst       Date:  1994-06-01       Impact factor: 13.506

6.  Practical p-value adjustment for optimally selected cutpoints.

Authors:  S G Hilsenbeck; G M Clark
Journal:  Stat Med       Date:  1996-01-15       Impact factor: 2.373

7.  Cutpoint selection for discretizing a continuous covariate for generalized estimating equations.

Authors:  Gisela Tunes-da-Silva; John P Klein
Journal:  Comput Stat Data Anal       Date:  2011-01-01       Impact factor: 1.681

8.  Categorising continuous variables.

Authors:  D G Altman
Journal:  Br J Cancer       Date:  1991-11       Impact factor: 7.640

9.  Suboptimal analysis using 'optimal' cutpoints.

Authors:  D G Altman
Journal:  Br J Cancer       Date:  1998-08       Impact factor: 7.640

10.  A novel approach to determine two optimal cut-points of a continuous predictor with a U-shaped relationship to hazard ratio in survival data: simulation and application.

Authors:  Yimin Chen; Jialing Huang; Xianying He; Yongxiang Gao; Gehendra Mahara; Zhuochen Lin; Jinxin Zhang
Journal:  BMC Med Res Methodol       Date:  2019-05-09       Impact factor: 4.615

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