Different lipid metabolic profiles and their associated genes in sessile serrated adenoma or polyps compared to hyperplastic polyps.

The serrated pathway is important in the development of colorectal cancer; currently, knowledge about the lipid metabolism profiles of serrated lesions is limited. Clinical characteristics were compared via Pearson's chi-squared test, nonparametric Kruskal-Wallis test and ANOVA. For some missing values, the MCAR test and multiple imputations were performed. Compared to patients with HP, the rates of younger patients (<50) and male patients with SSA or SSP were increased (P<0.05). Additionally, the BMI index and triglyceride levels were increased in patients with SSA or SSP. Inversely, patients with SSA/P had lower levels of HDL (P<0.05). Interestingly, the value of uric acid and tumor size in SSA/P patients tended to be greater than those in HP patients, and the ratio of patients who smoked was also increased. Other characteristics, such as LDL, ALB, γ-GT, and the N/L ratio, were similar among the subtypes of serrated lesions. Analysis of GEO data (GSE43841) showed that 9 genes were associated with lipid metabolism, including ADRB3, DEGS2, PRKACB, SLC44A1, and CA4. PRKACB was downregulated in SSA/P tissue compared to HP tissue samples from the GSE76987 dataset and our hospital. In conclusion, compared to benign HP, lower HDL levels and higher triglyceride levels tended to occur in CRC precursor SSA/P lesions, and these factors may be associated with metabolic genomic markers, such as PRKACB. AJCR