| Literature DB >> 31390550 |
Christopher R Cederroth1, Urs Albrecht2, Joseph Bass3, Steven A Brown4, Jonas Dyhrfjeld-Johnsen5, Frederic Gachon6, Carla B Green7, Michael H Hastings8, Charlotte Helfrich-Förster9, John B Hogenesch10, Francis Lévi11, Andrew Loudon12, Gabriella B Lundkvist13, Johanna H Meijer14, Michael Rosbash15, Joseph S Takahashi16, Michael Young17, Barbara Canlon18.
Abstract
The importance of circadian biology has rarely been considered in pre-clinical studies, and even more when translating to the bedside. Circadian biology is becoming a critical factor for improving drug efficacy and diminishing drug toxicity. Indeed, there is emerging evidence showing that some drugs are more effective at nighttime than daytime, whereas for others it is the opposite. This suggests that the biology of the target cell will determine how an organ will respond to a drug at a specific time of the day, thus modulating pharmacodynamics. Thus, it is now time that circadian factors become an integral part of translational research.Entities:
Keywords: ADME; chronotherapy; circadian biology; clock genes; drug metabolism; translation
Mesh：
Year: 2019 PMID： 31390550 PMCID： PMC6881776 DOI： 10.1016/j.cmet.2019.06.019
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287