Literature DB >> 356763

Intra-articular methotrexate. Clinical and laboratory study in rheumatoid and psoriatic arthritis.

G H Hall, B J Jones, A C Head, V E Jones.   

Abstract

The effects of intra-articular methotrexate (MTX) were compared with saline in 20 patients with persistent knee effusions due to rheumatoid arthritis (15) and psoriasis (5) in a double-blind pilot study. Clinical improvement was seen in most patients given either MTX or saline and was attributed to joint irrigation during arthroscopy and the placebo effects. MTX had a local anti-inflammatory effect in the psoriatic arthropathies; the percentages of polymorphonuclear cells and pyroninophilic mononuclear cells in synovial fluids fell sharply. Intraarticular hydrocortisone acetate was not anti-inflammatory in 2 psoriatic patients treated subsequently. The anti-inflammatory action of MTX in joints may resemble its effectiveness in controlling the rash of psoriasis.

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Year:  1978        PMID： 356763      PMCID： PMC1000243          DOI： 10.1136/ard.37.4.351

Source DB:  PubMed          Journal:  Ann Rheum Dis        ISSN： 0003-4967            Impact factor:   19.103


  12 in total

Review 1.  The clinical pharmacology of antineoplastic agents (first of two parts).

Authors:  B A Chabner; C E Myers; C N Coleman; D G Johns
Journal:  N Engl J Med       Date:  1975-05-22       Impact factor: 91.245

2.  The mechanism of action of methotrexate. III. Requirement of free intracellular methotrexate for maximal suppression of (14C)formate incorporation into nucleic acids and protein.

Authors:  J C White; S Loftfield; I D Goldman
Journal:  Mol Pharmacol       Date:  1975-05       Impact factor: 4.436

3.  METHOTREXATE THERAPY IN PSORIATIC ARTHRITIS; DOUBLE-BLIND STUDY ON 21 PATIENTS.

Authors:  R L BLACK; W M O'BRIEN; E J VANSCOTT; R AUERBACH; A Z EISEN; J J BUNIM
Journal:  JAMA       Date:  1964-09-07       Impact factor: 56.272

4.  SYNOVIAL LINING CELLS AND PLASMA CELLS IN THE SYNOVIAL MEMBRANE IN CASES OF CLASSIC RHEUMATOID ARTHRITIS. A STUDY BASED PARTLY ON HISTOLOGICAL SECTIONS STAINED BY THE METHYL GREEN-PYRONINE METHOD.

Authors:  P E JOHANSEN
Journal:  Acta Rheumatol Scand       Date:  1965

5.  Chemical action and pharmacology of methotrexate, azathioprine and cyclophosphamide in man.

Authors:  J R Bertino
Journal:  Arthritis Rheum       Date:  1973 Jan-Feb

6.  Relation of cellular infiltration of rheumatoid synovial membrane to its immune response.

Authors:  M Ziff
Journal:  Arthritis Rheum       Date:  1974 May-Jun

7.  Effects of intra-articular corticosteroids in vivo on synovial fluid variables in rheumatoid synovitis.

Authors:  E J Goetzl; N E Bianco; J S Alpert; C B Sledge; P H Schur
Journal:  Ann Rheum Dis       Date:  1974-01       Impact factor: 19.103

8.  Intra-articular methotrexate in rheumatoid arthritis.

Authors:  J S Marks; I M Stewart; J A Hunter
Journal:  Lancet       Date:  1976-10-16       Impact factor: 79.321

9.  Letter: Intra-articular methotrexate.

Authors:  G H Hall; A C Head
Journal:  Lancet       Date:  1975-08-30       Impact factor: 79.321

Review 10.  Methotrexate.

Authors:  G D Weinstein
Journal:  Ann Intern Med       Date:  1977-02       Impact factor: 25.391
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  8 in total

1.  [A history of joint puncture and injection].

Authors:  H Kaiser
Journal:  Z Rheumatol       Date:  2011-01       Impact factor: 1.372

Review 2.  Antirheumatic drug concentrations in human synovial fluid and synovial tissue. Observations on extravascular pharmacokinetics.

Authors:  W J Wallis; P A Simkin
Journal:  Clin Pharmacokinet       Date:  1983 Nov-Dec       Impact factor: 6.447

Review 3.  A risk-benefit assessment of intra-articular corticosteroids in rheumatic disorders.

Authors:  J A Hunter; T H Blyth
Journal:  Drug Saf       Date:  1999-11       Impact factor: 5.606

4.  Intra-articular methotrexate in the treatment of rheumatoid arthritis and psoriatic arthritis: a clinical and sonographic study.

Authors:  Annamaria Iagnocco; Angela Cerioni; Giulio Coari; Alejandra Ossandon; Raffaele Masciangelo; Guido Valesini
Journal:  Clin Rheumatol       Date:  2005-06-10       Impact factor: 2.980

5.  Rheumatoid knee synovitis successfully treated with intra-articular rifamycin SV.

Authors:  I Caruso; F Montrone; M Fumagalli; C Patrono; S Santandrea; M C Gandini
Journal:  Ann Rheum Dis       Date:  1982-06       Impact factor: 19.103

6.  Intra-articular methotrexate versus corticosteroid injections in medium-sized joints of rheumatoid arthritis patients-an intervention study.

Authors:  Mohmad Attia Mortada; Shimaa Mustafa Abdelwhab; Mohmad H Elgawish
Journal:  Clin Rheumatol       Date:  2017-09-30       Impact factor: 2.980

7.  Methotrexate for psoriatic arthritis.

Authors:  Tom D Wilsdon; Samuel L Whittle; Tilenka Rj Thynne; Arduino A Mangoni
Journal:  Cochrane Database Syst Rev       Date:  2019-01-18

8.  Safety of Intra-articular Methotrexate Injection With and Without Electroporation for Inflammatory Small Joints in Patients With Rheumatoid Arthritis.

Authors:  Masahiro Tada; Kentaro Inui; Tadashi Okano; Kenji Mamoto; Tatsuya Koike; Hiroaki Nakamura
Journal:  Clin Med Insights Arthritis Musculoskelet Disord       Date:  2019-11-04
  8 in total

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