| Literature DB >> 35672242 |
Blaire E Barton1, Cindy H Chau1, William D Figg2.
Abstract
Checkpoint blockade and adoptive T cell therapy are efficacious in some patients, but many do not respond to these immunotherapies. Chou et al. recently elucidated the characteristics of a new cell population with greater cytotoxicity, improved tumor homing, and reduced exhaustion compared to conventional cytotoxic T cells. These cells may improve the efficacy of cancer immunotherapies, especially for patients refractory or unresponsive to current approaches. Published by Elsevier Inc.Entities:
Keywords: T cell exhaustion; immunosurveillance; immunotherapy; innate-like cytotoxic T cells; tumor homing
Mesh:
Year: 2022 PMID: 35672242 PMCID: PMC9308744 DOI: 10.1016/j.trecan.2022.05.003
Source DB: PubMed Journal: Trends Cancer ISSN: 2405-8025