Hong Cui1, Leilei Yu2, Hua Li3, Hongling Wang1, Wenwen Liang1, Huige Wang4, Huifeng Wang5. 1. Department of Ultrasound, The Affiliated Taian City Central Hospital of Qingdao University, No.29 Longtan Road, Taian 271000, Shandong, People's Republic of China. 2. Department of Endocrinology, The Affiliated Taian City Central Hospital of Qingdao University, No.29 Longtan Road, Taian 271000, Shandong, People's Republic of China. 3. Department of Gynecology, The Affiliated Taian City Central Hospital of Qingdao University, No.29 Longtan Road, Taian 271000, Shandong, People's Republic of China. 4. Department of Medical Oncology, The Affiliated Taian City Central Hospital of Qingdao University, No.29 Longtan Road, Taian 271000, Shandong, People's Republic of China. 5. Department of Ultrasound, The Affiliated Taian City Central Hospital of Qingdao University, No.29 Longtan Road, Taian 271000, Shandong, People's Republic of China. wanghuifeng0303@126.com.
Abstract
PURPOSE: This study aimed to investigate whether placental parameters measured by three-dimensional ultrasound are associated with preeclampsia (PE) and small-for-gestational-age (SGA). METHODS: In total, 1163 pregnancies at 11-14 weeks of gestation were recruited between October 8, 2020, and April 30, 2021. Placenta volume (PV), placental bed vascularization flow index (PBVFI), and uterine arteries pulse index (UtA-PI) were measured. Placental quotient (PQ = PV/weeks of gestation) was calculated. All participants were re-examined 4 weeks later. The placental volume growth rate (PVGR = placental volume difference between the two examinations/interval days) was also calculated. Patients were divided into four groups by the gestational age at the onset of PE and birth weight: early-onset PE (E-PE, n = 18), late-onset PE (L-PE, n = 36), isolated SGA5 (birth weight less than the fifth percentile for gestational age without PE, n = 9), and unaffected (n = 1100) groups. RESULTS: A predictive model for E-PE was established, which consisted of unnatural conception, chronic hypertension, PBVFI (of second examination), and PVGR for E-PE; 94.4% sensitivity and 96.7% specificity by receiver operating characteristic curve analysis. CONCLUSIONS: Overall, decreased placental growth potential and low placental bed perfusion in the early second trimester have potential in predicting E-PE.
PURPOSE: This study aimed to investigate whether placental parameters measured by three-dimensional ultrasound are associated with preeclampsia (PE) and small-for-gestational-age (SGA). METHODS: In total, 1163 pregnancies at 11-14 weeks of gestation were recruited between October 8, 2020, and April 30, 2021. Placenta volume (PV), placental bed vascularization flow index (PBVFI), and uterine arteries pulse index (UtA-PI) were measured. Placental quotient (PQ = PV/weeks of gestation) was calculated. All participants were re-examined 4 weeks later. The placental volume growth rate (PVGR = placental volume difference between the two examinations/interval days) was also calculated. Patients were divided into four groups by the gestational age at the onset of PE and birth weight: early-onset PE (E-PE, n = 18), late-onset PE (L-PE, n = 36), isolated SGA5 (birth weight less than the fifth percentile for gestational age without PE, n = 9), and unaffected (n = 1100) groups. RESULTS: A predictive model for E-PE was established, which consisted of unnatural conception, chronic hypertension, PBVFI (of second examination), and PVGR for E-PE; 94.4% sensitivity and 96.7% specificity by receiver operating characteristic curve analysis. CONCLUSIONS: Overall, decreased placental growth potential and low placental bed perfusion in the early second trimester have potential in predicting E-PE.
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