Literature DB >> 3567017

Pharmacokinetic profile of indoprofen in elderly subjects.

B Lund, C Egsmose, O Knudsen, R B Andersen.   

Abstract

Multiple dosing four times daily for 7 days of indoprofen 200 mg, a non-steroidal anti-inflammatory drug with a short half-life (t1/2), revealed drug accumulation in eight elderly subjects. This indicates a substantially longer t1/2 (11 h) than that reported in young persons (3 h). A reduction in dose compared to younger subjects is recommended in elderly patients with osteoarthritis.

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Year:  1986        PMID： 3567017      PMCID： PMC1401207          DOI： 10.1111/j.1365-2125.1986.tb02964.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  18 in total

1.  Kinetics of indomethacin absorption, elimination, and enterohepatic circulation in man.

Authors:  K C Kwan; G O Breault; E R Umbenhauer; F G McMahon; D E Duggan
Journal:  J Pharmacokinet Biopharm       Date:  1976-06

2.  Pharmacokinetic studies of indoprofen in healthy volunteers and in patients.

Authors:  I Caruso; G Corvi; L M Fuccella; E Moro; G Sacchetti; V Tamassia; G P Tosolini
Journal:  Int J Clin Pharmacol Biopharm       Date:  1977-09

3.  Decreased body clearance of diflunisal in renal insufficiency--an alternative explanation.

Authors:  G Levy
Journal:  Br J Clin Pharmacol       Date:  1979-12       Impact factor: 4.335

4.  Pharmacokinetics of indomethacin.

Authors:  G Alván; M Orme; L Bertilsson; R Ekstrand; L Palmér
Journal:  Clin Pharmacol Ther       Date:  1975-09       Impact factor: 6.875

5.  Biotransformation of diflunisal and renal excretion of its glucuronides in renal insufficiency.

Authors:  R Verbeeck; T B Tjandramaga; A Mullie; R Verbesselt; R Verberckmoes; P J de Schepper
Journal:  Br J Clin Pharmacol       Date:  1979-03       Impact factor: 4.335

6.  Estimation of kinetic parameters from a two-point determination of the drug cumulation factor.

Authors:  T D Bjornsson; D G Shand
Journal:  Clin Pharmacol Ther       Date:  1979-11       Impact factor: 6.875

7.  Indomethacin in rheumatoid arthritis: clinical effects, pharmacokinetics, and platelet studies in responders and nonresponders.

Authors:  N Baber; L D Halliday; W J van den Heuvel; R W Walker; R Sibeon; J P Keenan; T Littler; M L Orme
Journal:  Ann Rheum Dis       Date:  1979-04       Impact factor: 19.103

8.  Piroxicam pharmacokinetics in man: aspirin and antacid interaction studies.

Authors:  D C Hobbs; T M Twomey
Journal:  J Clin Pharmacol       Date:  1979 May-Jun       Impact factor: 3.126

9.  Reduced clofibric acid clearance in renal dysfunction is due to a futile cycle.

Authors:  P J Meffin; D M Zilm; J R Veenendaal
Journal:  J Pharmacol Exp Ther       Date:  1983-12       Impact factor: 4.030

10.  Effect of age and sex on human drug metabolism.

Authors:  K O'Malley; J Crooks; E Duke; I H Stevenson
Journal:  Br Med J       Date:  1971-09-11
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  1 in total

Review 1.  Hepatic drug metabolism and aging.

Authors:  C Durnas; C M Loi; B J Cusack
Journal:  Clin Pharmacokinet       Date:  1990-11       Impact factor: 6.447
  1 in total

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