Literature DB >> 35668164

A diastereoselective three-component reaction for the assembly of succinimide and isatin hybrid molecules with potent anticancer activities.

Haoxuan Yuan1, Yinfeng Guo1, Zhijing Zhang1, Hongkai Sha1, Yicheng He1, Xinfang Xu2, Wenhao Hu3.   

Abstract

A Rh2(OAc)4 catalyzed three-component reaction of vinyl diazosuccinimides with alcohols and isatins has been reported, which provides a practical assess to the direct assembly of succinimide and isatin hybrid molecules in good-to-high yields with excellent stereoselectivity. The antiproliferation activity of these synthesized succinimide and isatin hybrid products has been tested via the CCK8 assay in different cancer cell lines, and compounds 4g (SJSA-1, IC50 = 3.82 μM) and 4r (HCT-116, IC50 = 9.02 μM) exhibit higher anticancer potency than other tested compounds.
© 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.

Entities:  

Keywords:  Anticancer activity; Hybrid molecule; Isatin; Succinimide; Three-component reaction

Year:  2022        PMID： 35668164     DOI： 10.1007/s11030-022-10457-x

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  29 in total

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