Literature DB >> 35662806

Risks related to a possible reduction of the waiting period for dogs after rabies antibody titration to 30 days compared with 90 days of the current EU legislative regime.

Julio Alvarez, Søren Saxmose Nielsen, Emmanuelle Robardet, Arjan Stegeman, Steven Van Gucht, Vlad Vuta, Sotiria-Eleni Antoniou, Inma Aznar, Alexandra Papanikolaou, Helen Clare Roberts.   

Abstract

EFSA received a mandate from the European Commission to assess the risks related to a possible reduction of the waiting period after rabies antibody titration test to 30 days compared with 90 days of the current EU legislation, for dogs moving from certain non-EU countries to the EU. This Scientific Report assessed the probability of introduction of rabies into the EU through commercial and non-commercial movements of vaccinated dogs with a positive titration test (≥ 0.5 IU/mL) if the waiting period decreases from 90 to 30 days. Assuming that all the legal requirements are complied with, the risk of transmission of rabies through the movement of a vaccinated dog is related to the risk of introducing an animal incubating rabies that was infected before the day of vaccination or shortly after vaccination but before the development of immunity (21 days post-vaccination). Using published data on the incubation period for experimental and field cases in dogs and considering the rabies incidence data in certain countries, the aggregated probability for the annual introduction of rabies through dogs was assessed. Considering the uncertainty related to the duration of the incubation period, the number of imported dogs, and the disease incidence in some countries it was concluded with a 95% certainty that the maximum number of rabies-infected imported dogs complying with the regulations in a 20-year period could increase from 5 to 20 when decreasing the waiting period from 90 to 30 days. Nevertheless, the potential impact of even a small increase in probability means the risk is increased for a region like the EU where rabies has long been a focus for eradication, to protect human and animal health.
© 2022 Wiley‐VCH Verlag GmbH & Co. KgaA on behalf of the European Food Safety Authority.

Entities:  

Keywords:  antibody titration test; dog; import; rabies; vaccination; waiting period

Year:  2022        PMID: 35662806      PMCID: PMC9161159          DOI: 10.2903/j.efsa.2022.7350

Source DB:  PubMed          Journal:  EFSA J        ISSN: 1831-4732


  77 in total

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Authors:  M Catchpole; L Thomas; D Morgan; K Brown; D Turbitt; H Kirkbride
Journal:  Euro Surveill       Date:  2008-05-08

2.  Multivariate analysis of the immune response to different rabies vaccines.

Authors:  E Bommier; L Chapat; A L Guiot; F Hilaire; C Cariou; H Poulet; D Pialot; K De Luca
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Journal:  Arch Virol       Date:  2017-08-01       Impact factor: 2.574

4.  Recovery from clinical rabies of 2 dogs inoculated with a rabies virus strain from Ethiopia.

Authors:  M Fekadu; G M Baer
Journal:  Am J Vet Res       Date:  1980-10       Impact factor: 1.156

5.  Walking the dog and moving the cat: rabies serology in the context of international pet travel schemes.

Authors:  R G Zanoni; Ph Bugnon; E Deranleau; T M V Nguyen; D Brügger
Journal:  Schweiz Arch Tierheilkd       Date:  2010-12       Impact factor: 0.845

6.  Risks related to a possible reduction of the waiting period for dogs after rabies antibody titration to 30 days compared with 90 days of the current EU legislative regime.

Authors:  Julio Alvarez; Søren Saxmose Nielsen; Emmanuelle Robardet; Arjan Stegeman; Steven Van Gucht; Vlad Vuta; Sotiria-Eleni Antoniou; Inma Aznar; Alexandra Papanikolaou; Helen Clare Roberts
Journal:  EFSA J       Date:  2022-06-02

7.  Postexposure prophylaxis for prevention of rabies in dogs.

Authors:  Cathleen A Hanlon; Michael Niezgoda; Charles E Rupprecht
Journal:  Am J Vet Res       Date:  2002-08       Impact factor: 1.156

8.  Post-exposure prophylaxis (PEP) of rabies-infected Indian street dogs.

Authors:  R Manickama; M D Basheer; R Jayakumar
Journal:  Vaccine       Date:  2008-12-02       Impact factor: 3.641

9.  A recombinant pseudorabies virus expressing rabies virus glycoprotein: safety and immunogenicity in dogs.

Authors:  Ziguo Yuan; Shoufeng Zhang; Ye Liu; Fei Zhang; Anthony R Fooks; Qianxue Li; Rongliang Hu
Journal:  Vaccine       Date:  2008-01-22       Impact factor: 3.641

10.  A recombinant rabies virus encoding two copies of the glycoprotein gene confers protection in dogs against a virulent challenge.

Authors:  Xiaohui Liu; Youtian Yang; Zhaojin Sun; Jing Chen; Jun Ai; Can Dun; Zhen F Fu; Xuefeng Niu; Xiaofeng Guo
Journal:  PLoS One       Date:  2014-02-03       Impact factor: 3.240

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  1 in total

1.  Risks related to a possible reduction of the waiting period for dogs after rabies antibody titration to 30 days compared with 90 days of the current EU legislative regime.

Authors:  Julio Alvarez; Søren Saxmose Nielsen; Emmanuelle Robardet; Arjan Stegeman; Steven Van Gucht; Vlad Vuta; Sotiria-Eleni Antoniou; Inma Aznar; Alexandra Papanikolaou; Helen Clare Roberts
Journal:  EFSA J       Date:  2022-06-02
  1 in total

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