| Literature DB >> 35654973 |
Varun Warrier1, Xinhe Zhang2, Patrick Reed2, Alexandra Havdahl3,4,5, Tyler M Moore6,7, Freddy Cliquet8, Claire S Leblond8, Thomas Rolland8, Anders Rosengren9,10, David H Rowitch11, Matthew E Hurles12, Daniel H Geschwind13,14,15,16, Anders D Børglum9,17,18, Elise B Robinson19,20,21, Jakob Grove9,17,18,22, Hilary C Martin12, Thomas Bourgeron8, Simon Baron-Cohen23.
Abstract
The substantial phenotypic heterogeneity in autism limits our understanding of its genetic etiology. To address this gap, here we investigated genetic differences between autistic individuals (nmax = 12,893) based on core and associated features of autism, co-occurring developmental disabilities and sex. We conducted a comprehensive factor analysis of core autism features in autistic individuals and identified six factors. Common genetic variants were associated with the core factors, but de novo variants were not. We found that higher autism polygenic scores (PGS) were associated with lower likelihood of co-occurring developmental disabilities in autistic individuals. Furthermore, in autistic individuals without co-occurring intellectual disability (ID), autism PGS are overinherited by autistic females compared to males. Finally, we observed higher SNP heritability for autistic males and for autistic individuals without ID. Deeper phenotypic characterization will be critical in determining how the complex underlying genetics shape cognition, behavior and co-occurring conditions in autism.Entities:
Mesh：
Year: 2022 PMID： 35654973 PMCID： PMC9470531 DOI： 10.1038/s41588-022-01072-5
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 41.307