Keita Suzuki1, Hiromasa Tsujiguchi1,2,3, Akinori Hara1,2,3, Oanh Kim Pham1, Sakae Miyagi3,4, Thao Thi Thu Nguyen5, Haruki Nakamura1, Fumihiko Suzuki2,6, Tomoko Kasahara2, Yukari Shimizu7, Yohei Yamada2, Yasuhiro Kambayashi8, Hirohito Tsuboi9, Takehiro Sato3,10, Takayuki Kannon3,10, Kazuyoshi Hosomichi3,10, Atsushi Tajima3,10, Toshinari Takamura11, Hiroyuki Nakamura1,2,3. 1. Department of Hygiene and Public Health, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan. 2. Department of Public Health, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan. 3. Kanazawa University Advanced Preventive Medical Sciences Research Center, Kanazawa, Ishikawa, Japan. 4. Innovative Clinical Research Center, Kanazawa University, Kanazawa, Ishikawa, Japan. 5. Department of Epidemiology, Faculty of Public Health, Haiphong University of Medicine and Pharmacy, Hai Phong, Vietnam. 6. Community Medicine Support Dentistry, Ohu University Hospital, Koriyama, Fukushima, Japan. 7. Department of Nursing, Faculty of Health Sciences, Komatsu University, Komatsu, Ishikawa, Japan. 8. Department of Public Health, Faculty of Veterinary Medicine, Okayama University of Science, Imabari, Ehime, Japan. 9. Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan. 10. Department of Bioinformatics and Genomics, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan. 11. Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa, Japan.
Abstract
Background: Previous studies examined the association between chronic pain (CP) and serum 25-hydroxyvitamin D (25(OH)D) concentrations; however, the findings obtained were inconsistent. Single nucleotide polymorphisms (SNP) associated with the transcriptional activity of the vitamin D receptor (VDR) gene may influence the association of 25(OH)D levels with CP. We aimed to clarify the association between CP, serum 25(OH)D concentration, and SNPs. Methods: In the Shika study, we performed a cross-sectional analysis of 551 participants older than 40 years who were asked whether they had been having persistent pain lasting for at least 3 months in any part of the body on a self-administered questionnaire. Serum 25(OH)D concentrations were assessed as a biomarker of the vitamin D status using a radioimmunoassay. rs731236, rs7975232, rs1544410, rs2228570, and rs11568820 were identified using peripheral blood samples, and participants were assigned to those with or without the minor allele for each SNP. Results: The prevalence of CP was 37.2%. We observed a tendency for lower 25(OH)D levels in participants with CP than in those without CP in the hetero/minor group of rs11568820, which is a polymorphism within the CDX2-binding site in the 1e promoter region of the VDR gene. Furthermore, a logistic regression analysis revealed that lower serum 25(OH)D concentrations were significantly associated with CP in the hetero/minor group, but not in the major group. Conclusion: These results suggest that sufficient serum 25(OH)D concentration reduces the risk of CP in individuals with the minor allele of the CDX2 polymorphism.
Background: Previous studies examined the association between chronic pain (CP) and serum 25-hydroxyvitamin D (25(OH)D) concentrations; however, the findings obtained were inconsistent. Single nucleotide polymorphisms (SNP) associated with the transcriptional activity of the vitamin D receptor (VDR) gene may influence the association of 25(OH)D levels with CP. We aimed to clarify the association between CP, serum 25(OH)D concentration, and SNPs. Methods: In the Shika study, we performed a cross-sectional analysis of 551 participants older than 40 years who were asked whether they had been having persistent pain lasting for at least 3 months in any part of the body on a self-administered questionnaire. Serum 25(OH)D concentrations were assessed as a biomarker of the vitamin D status using a radioimmunoassay. rs731236, rs7975232, rs1544410, rs2228570, and rs11568820 were identified using peripheral blood samples, and participants were assigned to those with or without the minor allele for each SNP. Results: The prevalence of CP was 37.2%. We observed a tendency for lower 25(OH)D levels in participants with CP than in those without CP in the hetero/minor group of rs11568820, which is a polymorphism within the CDX2-binding site in the 1e promoter region of the VDR gene. Furthermore, a logistic regression analysis revealed that lower serum 25(OH)D concentrations were significantly associated with CP in the hetero/minor group, but not in the major group. Conclusion: These results suggest that sufficient serum 25(OH)D concentration reduces the risk of CP in individuals with the minor allele of the CDX2 polymorphism.
Authors: Greta Snellman; Håkan Melhus; Rolf Gedeborg; Liisa Byberg; Lars Berglund; Lisa Wernroth; Karl Michaëlsson Journal: PLoS One Date: 2010-07-13 Impact factor: 3.240
Authors: Keira J A Johnston; Mark J Adams; Barbara I Nicholl; Joey Ward; Rona J Strawbridge; Amy Ferguson; Andrew M McIntosh; Mark E S Bailey; Daniel J Smith Journal: PLoS Genet Date: 2019-06-13 Impact factor: 6.020