| Literature DB >> 35632482 |
Gede Benny Setia Wirawan1, Ngakan Putu Anom Harjana1,2, Nur Wulan Nugrahani1, Pande Putu Januraga1,2.
Abstract
INTRODUCTION: The threat of new SARS-CoV-2 variants indicates the need to implement COVID-19 vaccine booster programs. The aim of this study was to identify the level of booster acceptance and its determinants.Entities:
Keywords: COVID-19; booster; health beliefs; socioeconomic status; trust; vaccine; vaccine hesitancy
Year: 2022 PMID: 35632482 PMCID: PMC9146460 DOI: 10.3390/vaccines10050724
Source DB: PubMed Journal: Vaccines (Basel) ISSN: 2076-393X
Demographic, COVID-19 infection, and vaccination history characteristics of respondents.
| Variables | Total | COVID-19 Booster Vaccine Acceptance | ||
|---|---|---|---|---|
| ( | Non-Acceptor | Planned Acceptor | Actual Acceptor | |
| ( | ( | ( | ||
| Demographics | ||||
| Sex, | ||||
| Male | 1123 (42.0) | 502 (42.9) | 427 (38.7) | 194 (48.1) |
| Female | 1551 (58.0) | 667 (57.1) | 675 (61.3) | 209 (51.9) |
| Age (years), median (IQR) | 29 (24–35) | 29 (23–35) | 29 (24–35) | 29 (25–36) |
| Location, | ||||
| Jakarta | 1894 (70.8) | 931 (79.6) | 797 (72.3) | 166 (41.2) |
| Bali | 780 (29.2) | 238 (20.4) | 305 (27.7) | 237 (58.8) |
| Religion, | ||||
| Islam | 1910 (71.4) | 978 (83.7) | 778 (70.6) | 154 (38.2) |
| Non-Islam | 764 (28.6) | 191 (16.3) | 324 (29.4) | 249 (61.8) |
| Education, | ||||
| Not completed high school | 222 (8.3) | 139 (11.9) | 75 (6.8) | 8 (2.0) |
| Completed high school | 1412 (52.8) | 725 (62.0) | 596 (54.1) | 91 (22.6) |
| Completed college | 1040 (38.9) | 305 (26.1) | 431 (39.1) | 304 (75.4) |
| Health insurance, | ||||
| Subsidized public insurance | 894 (33.1) | 460 (39.3) | 367 (33.3) | 57 (14.1) |
| Unsubsidized public insurance | 994 (37.2) | 339 (29.0) | 427 (38.7) | 228 (56.6) |
| Private insurance | 796 (29.8) | 370 (31.7) | 308 (27.9) | 118 (29.3) |
| Employment, | ||||
| Unemployed | 339 (12.7) | 184 (15.7) | 126 (11.4) | 29 (7.2) |
| Stay-at-home wife | 657 (24.6) | 351 (30.0) | 285 (25.9) | 21 (5.2) |
| Student | 318 (11.9) | 149 (12.7) | 132 (12.0) | 37 (9.2) |
| Part-time employment | 490 (18.3) | 213 (18.2) | 208 (18.9) | 69 (17.1) |
| Full-time employment | 870 (32.5) | 272 (23.3) | 351 (31.9) | 247 (61.3) |
| Monthly income, | ||||
| <IDR million | 823 (30.8) | 434 (37.1) | 317 (28.8) | 72 (17.9) |
| IDR 1 million–IDR 3 million | 752 (28.1) | 330 (28.2) | 310 (28.1) | 112 (27.8) |
| IDR 3 million–IDR 5 million | 674 (25.2) | 295 (25.2) | 281 (25.5) | 98 (24.3) |
| >IDR 5 million | 425 (15.9) | 110 (9.4) | 194 (17.6) | 121 (30) |
|
| ||||
| Vaccination history, | ||||
| 1 dose | 223 (8.3) | 168 (14.4) | 55 (5.0) | N/A |
| 2 doses | 2048 (76.6) | 1001 (85.6) | 1047 (95.0) | N/A |
| 3 doses | 403 (15.1) | N/A | N/A | 403 (100.0) |
| Vaccine type (1st and 2nd dose), | ||||
| Inactivated virus | 1635 (61.1) | 725 (62.0) | 602 (54.6) | 308 (76.4) |
| Viral vector | 786 (29.4) | 320 (27.4) | 415 (37.7) | 51 (12.7) |
| mRNA vaccine | 213 (8.0) | 99 (8.5) | 77 (7.0) | 37 (9.2) |
| Other or do not know | 40 (1.5) | 25 (2.1) | 8 (0.7) | 7 (1.7) |
| Booster scheme accepted, | ||||
| Booster for health worker | N/A | N/A | N/A | 108 (26.8) |
| Booster for general public | 295 (73.2) | |||
| Vaccine type (booster dose), | N/A | N/A | N/A | |
| Inactivated virus | 13 (3.2) | |||
| Viral vector | 95 (23.6) | |||
| mRNA vaccine | 286 (71.0) | |||
| Other or do not know | 9 (2.2) | |||
| COVID-19 Infection History | ||||
| Infection history, | ||||
| Never been infected | 2370 (88.6) | 1050 (89.8) | 963 (87.4) | 357 (88.6) |
| Infected, but never hospitalized | 242 (9.1) | 91 (7.8) | 115 (10.4) | 36 (8.9) |
| Infected and hospitalized | 62 (2.3) | 28 (2.4) | 24 (2.2) | 10 (2.5) |
| Infection history family/friends, | ||||
| No infection | 1521 (56.9) | 745 (63.7) | 598 (54.3) | 178 (44.2) |
| Infection only | 440 (16.5) | 170 (14.5) | 178 (16.2) | 92 (22.8) |
| Hospitalization | 281 (10.5) | 108 (9.2) | 124 (11.3) | 49 (12.2) |
| Mortality | 432 (16.2) | 146 (12.5) | 202 (18.3) | 84 (20.8) |
Media influence, trust, and health belief scores (range from 0 to 10) among respondents.
| Variables | Total | COVID-19 Booster Vaccine Acceptance | ||
|---|---|---|---|---|
| ( | Non-Acceptor | Planned Acceptor | Actual Acceptor | |
| ( | ( | ( | ||
| Media Influence | ||||
| Media influence, median (IQR) | ||||
| Influence of print media | 4.80 (1.60–6.40) | 3.60 (1.20–4.80) | 4.80 (2.40–6.40) | 4.00 (1.20–6.40) |
| Influence of television | 4.80 (3.60–6.40) | 4.80 (3.20–6.40) | 6.40 (4.80–8.00) | 4.80 (3.20–6.40) |
| Influence of radio | 3.20 (0.00–6.00) | 2.40 (0.00–4.80) | 4.80 (0.80–6.40) | 3.20 (0.00–4.80) |
| Influence of online media | 4.80 (3.60–6.40) | 4.80 (3.60–6.40) | 6.40 (4.80–8.00) | 4.80 (3.60–6.40) |
| Influence of social media | 4.80 (3.60–6.40) | 4.80 (3.20–6.40) | 6.40 (4.80–8.00) | 4.80 (3.20–6.40) |
|
| ||||
| Trust in authoritative sources, | 7.50 (5.83–8.33) | 7.08 (5.00–7.50) | 7.50 (7.08–9.18) | 7.50 (6.68–8.75) |
|
| ||||
| Perceived threat, median (IQR) | 6.46 (4.46–8.00) | 5.74 (3.80–7.46) | 7.10 (5.14–8.60) | 7.40 (5.46–8.40) |
| Perceived barriers, median (IQR) | 3.00 (0.66–5.34) | 4.00 (2.00–6.00) | 2.00 (0.00–5.00) | 1.66 (0.00–3.34) |
| Perceived harms, median (IQR) | 2.00 (0.40–4.00) | 3.20 (1.60–4.80) | 1.20 (0.00–2.80) | 1.20 (0.00–2.80) |
| Perceived benefits, median (IQR) | 8.00 (6.40–9.60) | 6.80 (5.60–8.00) | 8.80 (8.00–10.00) | 8.00 (7.20–9.60) |
Multinomial logistic regression model for COVID-19 vaccine booster acceptance.
| Variables | Planned to Accept | Already Accepted |
|---|---|---|
| aOR (95% CI) | aOR (95% CI) | |
| Health Belief | ||
| Perceived threat | ||
| Low | 1 | 1 |
| High | 1.69 (1.38–2.08) ** | 2.33 (1.73–3.14) ** |
| Perceived barriers | ||
| Low | 1 | 1 |
| High | 0.65 (0.52–0.81) ** | 0.31 (0.23–0.43) ** |
| Perceived harms | ||
| Low | 1 | 1 |
| High | 0.47 (0.38–0.59) ** | 0.47 (0.34–0.64) ** |
| Perceived benefits | ||
| Low | 1 | 1 |
| High | 2.81 (2.27–3.49) ** | 1.85 (1.35–2.54) ** |
|
| ||
| Influence of print media | ||
| Low | 1 | 1 |
| High | 1.51 (1.19–1.93) ** | 1.35 (0.96–1.90) |
| Influence of television | ||
| Low | 1 | 1 |
| High | 1.15 (0.86–1.53) | 0.65 (0.44–0.98) * |
| Influence of radio | ||
| Low | 1 | 1 |
| High | 0.95 (0.75–1.20) | 1.06 (0.76–1.48) |
| Influence of online media | ||
| Low | 1 | 1 |
| High | 0.95 (0.69–1.31) | 0.94 (0.60–1.47) |
| Influence of social media | ||
| Low | 1 | 1 |
| High | 1.64 (1.24–2.18) ** | 1.69 (1.14–2.50) ** |
| Trust in authoritative sources | ||
| Low | 1 | 1 |
| High | 1.45 (1.16–1.81) ** | 1.20 (0.87–1.66) |
|
| ||
| Sex | ||
| Male | 1 | 1 |
| Female | 1.18 (0.93–1.49) | 1.00 (0.73–1.37) |
| Age (per incremental years) | 1.00 (0.99–1.01) | 1.02 (1.00–1.04) * |
| Location | ||
| Jakarta | 1 | 1 |
| Bali | 1.07 (0.80–1.43) | 2.31 (1.59–3.36) ** |
| Religion | ||
| Islam | 1 | 1 |
| Non-Islam | 2.19 (1.62–2.98) ** | 3.22 (2.22–4.67) ** |
| Education | ||
| Not completed high school | 0.78 (0.55–1.11) | 0.76 (0.34–1.71) |
| Completed high school | 1 | 1 |
| Completed college | 1.43 (1.12–1.82) ** | 3.29 (2.31–4.70) ** |
| Employment | ||
| Full-time employment | 1 | 1 |
| Part-time employment | 0.81 (0.60–1.09) | 0.47 (0.32–0.71) ** |
| Student | 0.76 (0.50–1.17) | 0.36 (0.19–0.67) ** |
| Stay-at-home wife | 0.75 (0.54–1.06) | 0.14 (0.08–0.26) ** |
| Unemployed | 0.66 (0.46–0.96) | 0.22 (0.12–0.38) ** |
| Monthly income | ||
| <IDR 1 million | 1 | 1 |
| IDR 1 million–IDR 3 million | 1.08 (0.82–1.43) | 0.75 (0.46–1.22) |
| IDR 3 million–IDR 5 million | 1.03 (0.75–1.40) | 0.65 (0.38–1.10) |
| IDR 5 million | 1.58 (1.07–2.33) * | 1.20 (0.67–2.16) |
| Health insurance | ||
| Subsidized public insurance | 1 | 1 |
| Unsubsidized public insurance | 1.17 (0.92–1.49) | 2.24 (1.52–3.30) ** |
| Private insurance | 0.87 (0.68–2.33) | 1.22 (0.81–1.84) |
| COVID-19 infection history | ||
| Never infected | 1 | 1 |
| Infected, never hospitalized | 1.20 (0.85–1.70) | 0.76 (0.46–1.23) |
| Infected and hospitalized | 0.67 (0.34–1.31) | 0.60 (0.24–1.51) |
| COVID-19 history family/friends | ||
| No infection | 1 | 1 |
| Infection only | 1.15 (0.86–1.54) | 1.31 (0.89–1.94) |
| Hospitalization | 1.11 (0.79–1.56) | 1.12 (0.70–1.79) |
| Mortality | 1.24 (0.93–1.66) | 1.49 (1.00–2.22) |
* p < 0.05; ** p < 0.01.
Figure 1Changes to COVID-19 vaccine booster acceptance in hypothetical scenarios among initial non-acceptors (n = 1169). Significance of the changes compared to baseline acceptance were tested using the Wilcoxon signed-rank test (* p < 0.05; ** p < 0.01).