| Literature DB >> 35622333 |
Susanna Marquez1, Lmar Babrak2, Victor Greiff3, Kenneth B Hoehn1, William D Lees4, Eline T Luning Prak5, Enkelejda Miho2,6,7, Aaron M Rosenfeld5, Chaim A Schramm8, Ulrik Stervbo9,10.
Abstract
Adaptive immune receptor repertoires (AIRRs) are rich with information that can be mined for insights into the workings of the immune system. Gene usage, CDR3 properties, clonal lineage structure, and sequence diversity are all capable of revealing the dynamic immune response to perturbation by disease, vaccination, or other interventions. Here we focus on a conceptual introduction to the many aspects of repertoire analysis and orient the reader toward the uses and advantages of each. Along the way, we note some of the many software tools that have been developed for these investigations and link the ideas discussed to chapters on methods provided elsewhere in this volume.Entities:
Keywords: AIRR-seq; Analysis; B-cell receptor; Clonal structure; T-cell receptor
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Year: 2022 PMID： 35622333 DOI： 10.1007/978-1-0716-2115-8_17
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745