Literature DB >> 35617521

Patient-Derived Organoid Pharmacotyping Guides Precision Medicine for Pancreatic Cancer.

Yuqing Zhang1, Courtney W Houchen1, Min Li1,2.   

Abstract

The patient-derived organoids (PDO) platform recapitulates the phenotype, genotype, and molecular characteristics of primary tumors. High-throughput drug screening in terms of pharmacotyping using standard-of-care chemotherapy agents in the PDO platform has shown promising sensitivities to guide precision medicine for individual patients with pancreatic ductal adenocarcinoma (PDAC) within a clinically relevant time frame. See related article by Seppälä et al., p. 3296. ©2022 American Association for Cancer Research.

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Year:  2022        PMID： 35617521      PMCID： PMC9357115          DOI： 10.1158/1078-0432.CCR-22-1083

Source DB:  PubMed          Journal:  Clin Cancer Res        ISSN： 1078-0432            Impact factor:   13.801


  5 in total

1.  Pancreatic cancer organoids recapitulate disease and allow personalized drug screening.

Authors:  Else Driehuis; Arne van Hoeck; Kat Moore; Sigrid Kolders; Hayley E Francies; M Can Gulersonmez; Edwin C A Stigter; Boudewijn Burgering; Veerle Geurts; Ana Gracanin; Gergana Bounova; Folkert H Morsink; Robert Vries; Sylvia Boj; Johan van Es; G Johan A Offerhaus; Onno Kranenburg; Mathew J Garnett; Lodewyk Wessels; Edwin Cuppen; Lodewijk A A Brosens; Hans Clevers
Journal:  Proc Natl Acad Sci U S A       Date:  2019-12-09       Impact factor: 11.205

2.  Precision Medicine in Pancreatic Cancer: Patient-Derived Organoid Pharmacotyping Is a Predictive Biomarker of Clinical Treatment Response.

Authors:  Toni T Seppälä; Jacquelyn W Zimmerman; Reecha Suri; Haley Zlomke; Gabriel D Ivey; Annamaria Szabolcs; Christopher R Shubert; John L Cameron; William R Burns; Kelly J Lafaro; Jin He; Christopher L Wolfgang; Ying S Zou; Lei Zheng; David A Tuveson; James R Eshlemann; David P Ryan; Alec C Kimmelman; Theodore S Hong; David T Ting; Elizabeth M Jaffee; Richard A Burkhart
Journal:  Clin Cancer Res       Date:  2022-08-02       Impact factor: 13.801

3.  Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer.

Authors:  Pascal Belleau; Dannielle D Engle; Hervé Tiriac; Dennis Plenker; Astrid Deschênes; Tim D D Somerville; Fieke E M Froeling; Richard A Burkhart; Robert E Denroche; Gun-Ho Jang; Koji Miyabayashi; C Megan Young; Hardik Patel; Michelle Ma; Joseph F LaComb; Randze Lerie D Palmaira; Ammar A Javed; Jasmine C Huynh; Molly Johnson; Kanika Arora; Nicolas Robine; Minita Shah; Rashesh Sanghvi; Austin B Goetz; Cinthya Y Lowder; Laura Martello; Else Driehuis; Nicolas LeComte; Gokce Askan; Christine A Iacobuzio-Donahue; Hans Clevers; Laura D Wood; Ralph H Hruban; Elizabeth Thompson; Andrew J Aguirre; Brian M Wolpin; Aaron Sasson; Joseph Kim; Maoxin Wu; Juan Carlos Bucobo; Peter Allen; Divyesh V Sejpal; William Nealon; James D Sullivan; Jordan M Winter; Phyllis A Gimotty; Jean L Grem; Dominick J DiMaio; Jonathan M Buscaglia; Paul M Grandgenett; Jonathan R Brody; Michael A Hollingsworth; Grainne M O'Kane; Faiyaz Notta; Edward Kim; James M Crawford; Craig Devoe; Allyson Ocean; Christopher L Wolfgang; Kenneth H Yu; Ellen Li; Christopher R Vakoc; Benjamin Hubert; Sandra E Fischer; Julie M Wilson; Richard Moffitt; Jennifer Knox; Alexander Krasnitz; Steven Gallinger; David A Tuveson
Journal:  Cancer Discov       Date:  2018-05-31       Impact factor: 38.272

4.  Patient-derived organoids model treatment response of metastatic gastrointestinal cancers.

Authors:  Georgios Vlachogiannis; Somaieh Hedayat; Alexandra Vatsiou; Yann Jamin; Javier Fernández-Mateos; Khurum Khan; Andrea Lampis; Katherine Eason; Ian Huntingford; Rosemary Burke; Mihaela Rata; Dow-Mu Koh; Nina Tunariu; David Collins; Sanna Hulkki-Wilson; Chanthirika Ragulan; Inmaculada Spiteri; Sing Yu Moorcraft; Ian Chau; Sheela Rao; David Watkins; Nicos Fotiadis; Maria Bali; Mahnaz Darvish-Damavandi; Hazel Lote; Zakaria Eltahir; Elizabeth C Smyth; Ruwaida Begum; Paul A Clarke; Jens C Hahne; Mitchell Dowsett; Johann de Bono; Paul Workman; Anguraj Sadanandam; Matteo Fassan; Owen J Sansom; Suzanne Eccles; Naureen Starling; Chiara Braconi; Andrea Sottoriva; Simon P Robinson; David Cunningham; Nicola Valeri
Journal:  Science       Date:  2018-02-23       Impact factor: 47.728

5.  Patient-derived Organoid Pharmacotyping is a Clinically Tractable Strategy for Precision Medicine in Pancreatic Cancer.

Authors:  Toni T Seppälä; Jacquelyn W Zimmerman; Elisabetta Sereni; Dennis Plenker; Reecha Suri; Noah Rozich; Alex Blair; Dwayne L Thomas; Jonathan Teinor; Ammar Javed; Hardik Patel; John L Cameron; William R Burns; Jin He; David A Tuveson; Elizabeth M Jaffee; James Eshleman; Annamaria Szabolcs; David P Ryan; David T Ting; Christopher L Wolfgang; Richard A Burkhart
Journal:  Ann Surg       Date:  2020-09-01       Impact factor: 13.787
  5 in total

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