Matthew Camilleri1,2, Xiaoxi Zhang3, Meriel Norris4, Alex Monkhouse2,5, Alex Harvey4, Allison Wiseman4, Pratik Sinha6,7, Alex Hemsley8, Sophie Tang9, Arun Menon10, Smruti Sinmayee8, Mandy Jones4, Jim Buckley11, Ruth Johnson12, Thomas Medici13, Evelyn Corner4,14. 1. Anaesthetics Department, Peterborough City Hospital, Peterborough, UK. 2. 33N Ltd, London, UK. 3. Critical Care Unit, The Royal Marsden Hospital, London, UK. 4. Department of Health Sciences, Brunel University London, Kingston Lane, London, UK. 5. Anaesthetics Department, St Bartholomew's Hospital, London, UK. 6. Department of Medicine, Pulmonary and Critical Care Division, UCSF, San Francisco, CA, USA. 7. Department of Anaesthesia, UCSF, San Francisco, CA, USA. 8. Physiotherapy Department, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK. 9. Clinically-Led workforcE and Activity Redesign (CLEAR) Programme, Health Education England, London, UK. 10. Department of Anaesthesia, National Hospital for Neurology and Neurosurgery, London, UK. 11. Intensive Care Unit, Royal Free Hospital, London, UK. 12. Leicester Royal Infirmary, University Hospitals of Leicester, Infirmary Close, Leicester, UK. 13. Department of Anaesthesia, University College Hospital, London, UK. 14. Imperial College NHS Healthcare Trust, London, UK.