| Literature DB >> 35612781 |
Chuwei Yu1,2, Jing Chen3,4, Jin Ren5,6.
Abstract
Nonalcoholic fatty liver disease (NAFLD) is one of the most common metabolic diseases and closely associated with lipid disorder. Mitochondrion has been recognized to play a key role in lipid metabolism as the main site of energy metabolism in cells, and its dysfunction is involved in the progression of NAFLD. MicroRNAs (miRNAs), one of regulators in the pathogenesis of NAFLD, are discovered to modulate mitochondrial function by targeting mitochondrial proteins or mitochondrial-related factors, thereby improving or deteriorating NAFLD-associated pathologies. This review summarizes the differentially expressed miRNAs from clinical and experimental models of NAFLD with abilities in regulating mitochondrial function, expounds their underlying molecular mechanism and discusses their prospect and future research direction.Entities:
Keywords: Metabolic diseases; MiRNA; Mitochondrial dysfunction; Mitochondrion; NAFLD
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Year: 2022 PMID： 35612781 DOI： 10.1007/s11033-022-07503-0
Source DB: PubMed Journal: Mol Biol Rep ISSN： 0301-4851 Impact factor: 2.742