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Literature DB >> 35609545

Ribosome collisions: New ways to initiate ribosome rescue.

Abstract

When ribosomes collide while translating the same mRNA, a MutS-like protein can pry apart the leading ribosome and a nuclease can cut the mRNA between the collided ribosomes to initiate ribosome rescue and recycling.

Entities: Chemical

Mesh：

Substances：
Proteins
RNA, Messenger

Year: 2022 PMID： 35609545 PMCID： PMC9247869 DOI： 10.1016/j.cub.2022.04.038

Source DB: PubMed Journal: Curr Biol ISSN： 0960-9822 Impact factor: 10.900

Keyword Cloud
References

19 in total

1. SsrA-mediated protein tagging in the presence of miscoding drugs and its physiological role in Escherichia coli.

Authors: Tatsuhiko Abo; Koji Ueda; Takafumi Sunohara; Kazuko Ogawa; Hiroji Aiba
Journal: Genes Cells Date: 2002-07 Impact factor: 1.891

2. Ribosome rescue by tmRNA requires truncated mRNAs.

Authors: Natalia Ivanova; Michael Y Pavlov; Brice Felden; Måns Ehrenberg
Journal: J Mol Biol Date: 2004-04-16 Impact factor: 5.469

Review 3. Mechanisms of ribosome rescue in bacteria.

Authors: Kenneth C Keiler
Journal: Nat Rev Microbiol Date: 2015-04-13 Impact factor: 60.633

4. Alanine Tails Signal Proteolysis in Bacterial Ribosome-Associated Quality Control.

Authors: Iryna Lytvynenko; Helge Paternoga; Anna Thrun; Annika Balke; Tina A Müller; Christina H Chiang; Katja Nagler; George Tsaprailis; Simon Anders; Ilka Bischofs; Julie A Maupin-Furlow; Christian M T Spahn; Claudio A P Joazeiro
Journal: Cell Date: 2019-05-30 Impact factor: 41.582

Ribosome collisions: New ways to initiate ribosome rescue.

1. SsrA-mediated protein tagging in the presence of miscoding drugs and its physiological role in Escherichia coli.

2. Ribosome rescue by tmRNA requires truncated mRNAs.

Review 3. Mechanisms of ribosome rescue in bacteria.

4. Alanine Tails Signal Proteolysis in Bacterial Ribosome-Associated Quality Control.

5. Role of a peptide tagging system in degradation of proteins synthesized from damaged messenger RNA.

6. Ribosome rescue by Escherichia coli ArfA (YhdL) in the absence of trans-translation system.

7. Release of nonstop ribosomes is essential.

8. ArfA recognizes the lack of mRNA in the mRNA channel after RF2 binding for ribosome rescue.

9. Alkylative damage of mRNA leads to ribosome stalling and rescue by trans translation in bacteria.

10. Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria.