Lyne Daumas1,2, Raphaël Zory3,4, Philippe Robert5, Valeria Manera5. 1. Université Côte d'Azur, CoBTeK lab, Nice, France. daumas.l@chu-nice.fr. 2. Université Côte d'Azur, LAMHESS Lab, Nice, France. daumas.l@chu-nice.fr. 3. Université Côte d'Azur, LAMHESS Lab, Nice, France. 4. Institut Universitaire de France, Paris, France. 5. Université Côte d'Azur, CoBTeK lab, Nice, France.
Abstract
BACKGROUND: Apathy is common in neurocognitive disorders (NCD) and manifests as reduced goal-directed behaviors and activities. A decrease in everyday activities can also be due to fatigue, another common symptom in NCD. The aim of this study was to investigate if apathetic patients with NCD are more fatigued and more fatigable. METHOD: A self-report questionnaire and clinical functional tests assessed fatigue and fatigability in 30 apathetic vs 26 non-apathetic NCD participants. The Fatigue Severity Scale (FSS) was administered and a 15-s sustained maximal handgrip contraction and a 6-min walk test (6MWT) were performed. RESULTS: Apathetic subjects had higher FSS scores. A decrease in performance was observed in apathetic participants during the sustained maximal handgrip contraction but not the 6MWT. CONCLUSION: Higher self-reported fatigue and greater fatigability during the sustained maximal handgrip contraction test in apathetic subjects suggest the importance of assessing these symptoms in apathetic subjects to properly guide treatment. CLINICAL TRIAL REGISTRATION: NCT04573712.
BACKGROUND: Apathy is common in neurocognitive disorders (NCD) and manifests as reduced goal-directed behaviors and activities. A decrease in everyday activities can also be due to fatigue, another common symptom in NCD. The aim of this study was to investigate if apathetic patients with NCD are more fatigued and more fatigable. METHOD: A self-report questionnaire and clinical functional tests assessed fatigue and fatigability in 30 apathetic vs 26 non-apathetic NCD participants. The Fatigue Severity Scale (FSS) was administered and a 15-s sustained maximal handgrip contraction and a 6-min walk test (6MWT) were performed. RESULTS: Apathetic subjects had higher FSS scores. A decrease in performance was observed in apathetic participants during the sustained maximal handgrip contraction but not the 6MWT. CONCLUSION: Higher self-reported fatigue and greater fatigability during the sustained maximal handgrip contraction test in apathetic subjects suggest the importance of assessing these symptoms in apathetic subjects to properly guide treatment. CLINICAL TRIAL REGISTRATION: NCT04573712.
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