OBJECTIVE: Across all stages of Alzheimer disease (AD), apathy is the most common neuropsychiatric symptom. Studies using the Neuropsychiatric Inventory (NPI) have found that apathy is present in up to 70% of individuals with Alzheimer disease. One of the main difficulties in assessing apathy and other neuropsychiatric symptoms is the absence of reliable, objective measures. Motor activity assessment using ambulatory actigraphy could provide an indirect, objective evaluation of apathy. The aim of our study was to assess the relationship between apathy and daytime motor activity in AD, using ambulatory actigraphy. METHODS: One hundred seven AD outpatients wore a wrist actigraph (Motionlogger) during seven consecutive 24-hour periods to evaluate motor activity. Participants were divided into two subgroups according to their apathy subscores on the NPI: individuals with apathy (NPI-apathy subscores >4) and those without. Daytime mean motor activity scores were compared between the two subgroups. RESULTS: Individuals with AD who had symptoms of apathy (n = 43; age = 79 ± 4.7 years; Mini-Mental State Examination = 20.9 ± 4.8) had significantly lower daytime mean motor activity than AD patients without apathy (n = 64; age = 76.3 ± 7.7; Mini-Mental State Examination = 21.5 ± 4.7), while nighttime mean motor activity did not significantly differ between the two subgroups. CONCLUSIONS: Ambulatory actigraphy could be added to currently used questionnaires as a simple, objective technique for assessing apathy in the routine assessment of AD patients.
OBJECTIVE: Across all stages of Alzheimer disease (AD), apathy is the most common neuropsychiatric symptom. Studies using the Neuropsychiatric Inventory (NPI) have found that apathy is present in up to 70% of individuals with Alzheimer disease. One of the main difficulties in assessing apathy and other neuropsychiatric symptoms is the absence of reliable, objective measures. Motor activity assessment using ambulatory actigraphy could provide an indirect, objective evaluation of apathy. The aim of our study was to assess the relationship between apathy and daytime motor activity in AD, using ambulatory actigraphy. METHODS: One hundred seven AD outpatients wore a wrist actigraph (Motionlogger) during seven consecutive 24-hour periods to evaluate motor activity. Participants were divided into two subgroups according to their apathy subscores on the NPI: individuals with apathy (NPI-apathy subscores >4) and those without. Daytime mean motor activity scores were compared between the two subgroups. RESULTS: Individuals with AD who had symptoms of apathy (n = 43; age = 79 ± 4.7 years; Mini-Mental State Examination = 20.9 ± 4.8) had significantly lower daytime mean motor activity than ADpatients without apathy (n = 64; age = 76.3 ± 7.7; Mini-Mental State Examination = 21.5 ± 4.7), while nighttime mean motor activity did not significantly differ between the two subgroups. CONCLUSIONS: Ambulatory actigraphy could be added to currently used questionnaires as a simple, objective technique for assessing apathy in the routine assessment of ADpatients.
Authors: E Kelaiditi; M Cesari; M Canevelli; G Abellan van Kan; P-J Ousset; S Gillette-Guyonnet; P Ritz; F Duveau; M E Soto; V Provencher; F Nourhashemi; A Salvà; P Robert; S Andrieu; Y Rolland; J Touchon; J L Fitten; B Vellas Journal: J Nutr Health Aging Date: 2013-09 Impact factor: 4.075
Authors: P H Robert; A Konig; S Andrieu; F Bremond; I Chemin; P C Chung; J F Dartigues; B Dubois; G Feutren; R Guillemaud; P A Kenisberg; S Nave; B Vellas; F Verhey; J Yesavage; P Mallea Journal: J Nutr Health Aging Date: 2013 Impact factor: 4.075
Authors: Yvonne A W Hartman; Esther G A Karssemeijer; Lisanne A M van Diepen; Marcel G M Olde Rikkert; Dick H J Thijssen Journal: Dement Geriatr Cogn Disord Date: 2018-08-24 Impact factor: 2.959
Authors: Valérie Godefroy; Richard Levy; Arabella Bouzigues; Armelle Rametti-Lacroux; Raffaella Migliaccio; Bénédicte Batrancourt Journal: Int J Environ Res Public Health Date: 2021-07-23 Impact factor: 3.390