Literature DB >> 35604573

Heart failure with a preserved ejection fraction and the EMPEROR-Preserved Trial: a review of how we got here.

Tiago Tribolet de Abreu1.   

Abstract

Heart failure with a preserved ejection fraction (HFpEF), previously known as diastolic heart failure, was first recognized more than 50 years ago. In spite of all the advances in the knowledge of HFpEF, important questions remain, namely the fact that no therapy has been shown to improve outcomes in these patients. The EMPEROR-Preserved Trial, a trial on the use of empagliflozin on patients with HFpEF, published in October 2021, was the first trial to ever show a change in outcomes in these patients. This article reviews the history of HFpEF and the problems related to its definition and diagnosis over time, and critically reviews the results of the EMPEROR-Preserved Trial in light of these.
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Diastolic heart failure; Heart failure; Preserved ejection fraction

Mesh：

Year:  2022        PMID： 35604573     DOI： 10.1007/s10741-022-10244-8

Source DB:  PubMed          Journal:  Heart Fail Rev        ISSN： 1382-4147            Impact factor:   4.654


  13 in total

1.  Clinical aspects of cardiomyopathy.

Authors:  J F GOODWIN; H GORDON; A HOLLMAN; M B BISHOP
Journal:  Br Med J       Date:  1961-01-14

2.  Hemodynamic aspects of diffuse myocardial fibrosis.

Authors:  E D ROBIN; C S BURWELL
Journal:  Circulation       Date:  1957-11       Impact factor: 29.690

Review 3.  Heart Failure with Preserved Ejection Fraction.

Authors:  Margaret M Redfield
Journal:  N Engl J Med       Date:  2016-11-10       Impact factor: 91.245

4.  Impaired rate of left ventricular filling in idiopathic hypertrophic subaortic stenosis and valvular aortic stenosis.

Authors:  S Stewart; D T Mason; E Braunwald
Journal:  Circulation       Date:  1968-01       Impact factor: 29.690

Review 5.  Heart failure with preserved ejection fraction: a clinical dilemma.

Authors:  Michel Komajda; Carolyn S P Lam
Journal:  Eur Heart J       Date:  2014-03-11       Impact factor: 29.983

6.  2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure.

Authors:  Theresa A McDonagh; Marco Metra; Marianna Adamo; Roy S Gardner; Andreas Baumbach; Michael Böhm; Haran Burri; Javed Butler; Jelena Čelutkienė; Ovidiu Chioncel; John G F Cleland; Andrew J S Coats; Maria G Crespo-Leiro; Dimitrios Farmakis; Martine Gilard; Stephane Heymans; Arno W Hoes; Tiny Jaarsma; Ewa A Jankowska; Mitja Lainscak; Carolyn S P Lam; Alexander R Lyon; John J V McMurray; Alexandre Mebazaa; Richard Mindham; Claudio Muneretto; Massimo Francesco Piepoli; Susanna Price; Giuseppe M C Rosano; Frank Ruschitzka; Anne Kathrine Skibelund
Journal:  Eur Heart J       Date:  2021-09-21       Impact factor: 29.983

7.  Empagliflozin in Heart Failure with a Preserved Ejection Fraction.

Authors:  Stefan D Anker; Javed Butler; Gerasimos Filippatos; João P Ferreira; Edimar Bocchi; Michael Böhm; Hans-Peter Brunner-La Rocca; Dong-Ju Choi; Vijay Chopra; Eduardo Chuquiure-Valenzuela; Nadia Giannetti; Juan Esteban Gomez-Mesa; Stefan Janssens; James L Januzzi; Jose R Gonzalez-Juanatey; Bela Merkely; Stephen J Nicholls; Sergio V Perrone; Ileana L Piña; Piotr Ponikowski; Michele Senni; David Sim; Jindrich Spinar; Iain Squire; Stefano Taddei; Hiroyuki Tsutsui; Subodh Verma; Dragos Vinereanu; Jian Zhang; Peter Carson; Carolyn Su Ping Lam; Nikolaus Marx; Cordula Zeller; Naveed Sattar; Waheed Jamal; Sven Schnaidt; Janet M Schnee; Martina Brueckmann; Stuart J Pocock; Faiez Zannad; Milton Packer
Journal:  N Engl J Med       Date:  2021-08-27       Impact factor: 176.079

8.  How to diagnose heart failure with preserved ejection fraction: the HFA-PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC).

Authors:  Burkert Pieske; Carsten Tschöpe; Rudolf A de Boer; Alan G Fraser; Stefan D Anker; Erwan Donal; Frank Edelmann; Michael Fu; Marco Guazzi; Carolyn S P Lam; Patrizio Lancellotti; Vojtech Melenovsky; Daniel A Morris; Eike Nagel; Elisabeth Pieske-Kraigher; Piotr Ponikowski; Scott D Solomon; Ramachandran S Vasan; Frans H Rutten; Adriaan A Voors; Frank Ruschitzka; Walter J Paulus; Petar Seferovic; Gerasimos Filippatos
Journal:  Eur Heart J       Date:  2019-10-21       Impact factor: 29.983

9.  How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology.

Authors:  Walter J Paulus; Carsten Tschöpe; John E Sanderson; Cesare Rusconi; Frank A Flachskampf; Frank E Rademakers; Paolo Marino; Otto A Smiseth; Gilles De Keulenaer; Adelino F Leite-Moreira; Attila Borbély; István Edes; Martin Louis Handoko; Stephane Heymans; Natalia Pezzali; Burkert Pieske; Kenneth Dickstein; Alan G Fraser; Dirk L Brutsaert
Journal:  Eur Heart J       Date:  2007-04-11       Impact factor: 29.983
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